Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit
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June 28, 2013
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Structure-based drug design plays an important role in drug development. Pursuing multiple targets in parallel greatly increases the chance of success for lead discovery. The following article highlights how the Seattle Structural Genomics Center for Infectious Disease utilizes a multi-target approach for gene-to-structure determination of the PB2 influenza A subunit.
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Armour, B. L., Barnes, S. R., Moen, S. O., Smith, E., Raymond, A. C., Fairman, J. W., Stewart, L. J., Staker, B. L., Begley, D. W., Edwards, T. E., Lorimer, D. D. Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit. J. Vis. Exp. (76), e4225, doi:10.3791/4225 (2013).
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