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Engineering och evolution av syntetisk Adeno-associerat virus (AAV) Gene Therapy Vektorer via DNA Familj Skyffling
JoVE Journal
Imunologia e Infecção
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JoVE Journal Imunologia e Infecção
Engineering and Evolution of Synthetic Adeno-Associated Virus (AAV) Gene Therapy Vectors via DNA Family Shuffling
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Engineering och evolution av syntetisk Adeno-associerat virus (AAV) Gene Therapy Vektorer via DNA Familj Skyffling

28,074 Views

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21:55 min

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April 02, 2012

DOI:

10.3791/3819-v

DOI:
10.3791/3819-v

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21:55 min
April 02, 2012

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3 Views
, , , , , ,
1Cluster of Excellence CellNetworks, Department of Infectious Diseases, Virology,Heidelberg University, 2Department of Infectious Diseases, Virology,Heidelberg University

Tags

Adeno-associated Viral VectorsAAV Gene TherapyDNA Family ShufflingSynthetic VectorsTherapeutic Human Gene TransferRecombinant VectorsAAV SerotypesNatural VirusesSynthetic AAV VectorsDNA FragmentationAAV Capsid GenesPeptide DisplayHigh-throughput Method

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Kienle, E., Senís, E., Börner, K., Niopek, D., Wiedtke, E., Grosse, S., Grimm, D. Engineering and Evolution of Synthetic Adeno-Associated Virus (AAV) Gene Therapy Vectors via DNA Family Shuffling. J. Vis. Exp. (62), e3819, doi:10.3791/3819 (2012).

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