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Journal / Medicine / High Content Screening in Neurodegenerative…
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JoVE Journal Medicine
High Content Screening in Neurodegenerative Diseases
 

High Content Screening in Neurodegenerative Diseases

Article DOI: 10.3791/3452-v • 13:32 min • January 6th, 2012
January 6th, 2012 •
1, 2, 1
1Department of Clinical Genetics, VU University Medical Center, 2Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam

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We describe a methodology combining automated cell culturing with high-content imaging to visualize and quantify multiple cellular processes and structures, in a high-throughput manner. Such methods can aid in the further functional annotation of genomes as well as identify disease gene networks and potential drug targets.

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High Content Screening Neurodegenerative Diseases Functional Annotation Genomes Molecular Networks Drug Target Identification Genetic Risk Factors Pathogenic Mechanisms Functional Validation Genome Wide Association Study Parkinson's Disease Causative Variant Pathogenic Mechanism Associated Region Genes Phenotypes Traditional Cell Biology Techniques Molecular Networks Genetic Mutations Disease Phenotypes Network Complexity Drug Approval
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