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High Content Screening in Neurodegenerative Diseases
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January 06, 2012
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We describe a methodology combining automated cell culturing with high-content imaging to visualize and quantify multiple cellular processes and structures, in a high-throughput manner. Such methods can aid in the further functional annotation of genomes as well as identify disease gene networks and potential drug targets.
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High Content ScreeningNeurodegenerative DiseasesFunctional AnnotationGenomesMolecular NetworksDrug Target IdentificationGenetic Risk FactorsPathogenic MechanismsFunctional ValidationGenome Wide Association StudyParkinson’s DiseaseCausative VariantPathogenic MechanismAssociated RegionGenesPhenotypesTraditional Cell Biology TechniquesMolecular NetworksGenetic MutationsDisease PhenotypesNetwork ComplexityDrug Approval
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Jain, S., van Kesteren, R. E., Heutink, P. High Content Screening in Neurodegenerative Diseases. J. Vis. Exp. (59), e3452, doi:10.3791/3452 (2012).
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