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Journal / Immunology and Infection / Prediction of HIV-1 Coreceptor Usage (Tropism) by …
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Immunology and Infection

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JoVE Journal Immunology and Infection
Prediction of HIV-1 Coreceptor Usage (Tropism) by Sequence Analysis using a Genotypic Approach
 

Prediction of HIV-1 Coreceptor Usage (Tropism) by Sequence Analysis using a Genotypic Approach

Article DOI: 10.3791/3264-v • 07:06 min • December 1st, 2011
December 1st, 2011 •
1, 1, 1, 2, 1, 1, 3, 4, 5, 6, 1, 7, 2
1Institute of Virology, University of Cologne, 2Max Planck Institute for Informatics, 3Institute for Immune genetics, 4Department of Gastroenterology, Hepatology and Infectiology, University of Duesseldorf, 5Department of Dermatology, University of Essen, 6Department of Internal Medicine, University of Cologne, 7Augustinerinnen Hospital

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The prediction of the coreceptor usage of HIV-1 is required for the administration of a new class of antiretroviral drugs, i.e. coreceptor antagonists. It can be performed by sequence analysis of the env gene and subsequent interpretation through an internet based interpretation system (geno2pheno[coreceptor]).

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HIV-1 Coreceptor Usage Tropism Sequence Analysis Genotypic Approach Maraviroc CCR5 CXCR4 Env Protein R5 Virus X4 Virus Entry Inhibition Target Cell Trofile Assay MOTIVATE Study MERIT Study 1029 Study Monogram Assay Recombinant Tests Resistance Testing
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