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Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
JoVE Journal
Medicina
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JoVE Journal Medicina
Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

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11:10 min

November 16, 2011

DOI:

11:10 min
November 16, 2011

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Summary

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The hyperinsulinemic-euglycemic clamp, or insulin clamp, is the gold standard for assessing insulin action in vivo. A method for performing insulin clamps in mice is described. This includes a method for arterial catheterization that permits experiments to be performed in conscious, unrestrained mice with minimal stress.

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