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פיתוח נייד מסוג ספציפי נגד HIV gp120 aptamers למסירה siRNA
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Imunologia e Infecção
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JoVE Journal Imunologia e Infecção
Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery
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פיתוח נייד מסוג ספציפי נגד HIV gp120 aptamers למסירה siRNA

19,344 Views

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13:47 min

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June 23, 2011

DOI:

10.3791/2954-v

DOI:
10.3791/2954-v

•

13:47 min
June 23, 2011

•

5 Views
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1Department of Molecular and Cellular Biology,Beckman Research Institute of City of Hope, 2Graduate School of Biological Sciences,Beckman Research Institute of City of Hope, 3Shared Resource-DNA/RNA Peptide,Beckman Research Institute of City of Hope

Summary

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מספר 2'-Fluoro aptamers נגד HIV-RNA 1Ba-L gp120 עם זיקה nanomole מבודדים מספריית RNA על ידי<em> במבחנה</em> הליך Selex. חדש כפול פונקציה מעכבות אנטי gp120 aptamer-siRNA הכימרה נוצר מראה הבטחה רבה לטיפול אנטי HIV מערכתית.

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Cite this Article

Zhou, J., Li, H., Zhang, J., Piotr, S., Rossi, J. Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery. J. Vis. Exp. (52), e2954, doi:10.3791/2954 (2011).

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