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Immunology and Infection

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JoVE Journal Immunology and Infection
Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
 

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Article DOI: 10.3791/2532-v • 09:58 min • February 14th, 2011
February 14th, 2011 •
1, 1, 1
1Department of Microbiology and Immunology, Albert Einstein College of Medicine

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C57BL/6 mice have been used to study Hc pathogenesis and provide the best model. We are exploring the potential benefits of humoral immunity against this fungus and generated several mAbs [to histone H2B and a heat shock protein 60kDa] that we tested for their protective efficacy after intraperitoneal administration.

Tags

Passive Administration Monoclonal Antibodies H. Capsulatum Fungal Pathogens Histoplasmosis Antibody Therapy Virulence Factors MAbs Generation Solid Phase ELISA System Splenocytes Fusion C57BL/6 Mice Infection Assessment Mortality As An Endpoint Colony Forming Units (CFU) Survival Studies Intervention Efficacy Vaccine Efficacy Virulence Testing
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