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Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
JoVE Journal
Neurociência
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JoVE Journal Neurociência
Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models

DOI:
10.3791/1992-v

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11:51 min

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August 16, 2010

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, , ,
1Department of Neurological Surgery,University of California, San Francisco – UCSF

Capítulos

  • 00:04Título
  • 00:31Introduction
  • 01:08Tail Vein Injection
  • 02:49IP Injection
  • 04:01Oral Gavage
  • 05:21Acute Convection-Enhanced Delivery
  • 09:40In vivo Imaging
  • 10:07Representative Results
  • 11:21Conclusion

Summary

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Thorough preclinical testing of drugs that act in the central nervous system often involves assessing and comparing drug biodistribution in association with specific routes of administration. Here, three commonly used methods of systemic delivery (intravenous, intraperitoneal, and oral) as well as a method for local delivery (convection-enhanced delivery) are demonstrated in mice.

Tags

Systemic Drug DeliveryLocal Drug DeliveryCentral Nervous System DiseasesRodent ModelsTherapeutic EfficacyRoutes Of AdministrationAgent BiodistributionSystemic Delivery ApproachesLocal Delivery MethodsIntravenous InjectionIntraperitoneal InjectionOral GavageConvection-enhanced Delivery (CED)Fluorescently-labeled CompoundsIn Vivo Imaging

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