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Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
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Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
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August 16, 2010
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Thorough preclinical testing of drugs that act in the central nervous system often involves assessing and comparing drug biodistribution in association with specific routes of administration. Here, three commonly used methods of systemic delivery (intravenous, intraperitoneal, and oral) as well as a method for local delivery (convection-enhanced delivery) are demonstrated in mice.
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Systemic Drug DeliveryLocal Drug DeliveryCentral Nervous System DiseasesRodent ModelsTherapeutic EfficacyRoutes Of AdministrationAgent BiodistributionSystemic Delivery ApproachesLocal Delivery MethodsIntravenous InjectionIntraperitoneal InjectionOral GavageConvection-enhanced Delivery (CED)Fluorescently-labeled CompoundsIn Vivo Imaging
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Serwer, L., Hashizume, R., Ozawa, T., James, C. D. Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models. J. Vis. Exp. (42), e1992, doi:10.3791/1992 (2010).
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