This report provides a detailed description of a new remote navigation system based on magnetic driven forces, which has been recently introduced as a new robotic tool for human cardiac electrophysiology procedures.
New remote navigation systems have been developed to improve current limitations of conventional manually guided catheter ablation in complex cardiac substrates such as left atrial flutter. This protocol describes all the clinical and invasive interventional steps performed during a human electrophysiological study and ablation to assess the accuracy, safety and real-time navigation of the Catheter Guidance, Control and Imaging (CGCI) system. Patients who underwent ablation of a right or left atrium flutter substrate were included. Specifically, data from three left atrial flutter and two counterclockwise right atrial flutter procedures are shown in this report. One representative left atrial flutter procedure is shown in the movie. This system is based on eight coil-core electromagnets, which generate a dynamic magnetic field focused on the heart. Remote navigation by rapid changes (msec) in the magnetic field magnitude and a very flexible magnetized catheter allow real-time closed-loop integration and accurate, stable positioning and ablation of the arrhythmogenic substrate.
Catheter ablation of cardiac arrhythmias has become an effective treatment for different types of cardiac arrhythmias.1,2 Antiarrhythmic drugs have limited efficacy and often need to be withdrawn due to secondary effects or pro-arrhythmia.3 Thus, ablation is the only chance for a definitive treatment in many patients. Ablation procedures require moving catheters inside the vascular system and cardiac chambers to further identify the arrhythmia substrate before ablation. Proper catheter manipulation requires a skilled electrophysiologist working under fluoroscopic guidance. This may result in significant X-ray exposure, which is a risk for both patients and medical staff. In the last two decades, different navigation systems able to create electro-anatomical maps (EAM) have led to a decrease in X-ray exposure4 and to a better understanding of the substrate of cardiac arrhythmias.5-8 However, moving and placing catheters into specific regions of the heart still requires manual guidance, which makes these procedures highly dependent on operator skills. In addition, the constant beating of the heart makes stability one of the main problems of radiofrequency delivery in certain target cardiac regions. New remote navigation systems have been recently developed with the objective of overcoming such limitations and allowing the operators to be away from the X-ray source while they are moving the catheters inside the cardiovascular system.9-11 Two remote navigation systems are currently commercially available; the robotic catheter control system (Sensei system, Hansen Medical)12 and the magnetic catheter navigation system (Niobe system, Stereotaxis).13,14 The former is based on two steerable sheaths, through which any conventional catheter can be introduced for further manipulation via a pull-wire mechanism by a robotic arm fixed at a standard fluoroscopy table. The second system is based on two permanent magnets positioned on each side of the patient’s body to create a uniform magnetic field. Special catheters with magnets affixed to their distal end can be navigated within the cardiac chambers by changing the orientation of the external magnetic fields. Shortcomings such as safety and similar to manual navigation or weak tissue contact force and lack of real time catheter response are present in Sensei and Niobe, respectively.
In this report, we describe the features and potential ablation capabilities of a recently developed navigation system, the Catheter Guidance, Control and Imaging (CGCI).15,16
Patients who underwent ablation of a right or left atrium flutter substrate were included (Table 1). The presence of decompensated or severe systemic disease, thrombus within the left atrium, renal failure, age <18 years, body mass index >40 and pregnancy were the exclusion criteria. This protocol is part of the initial safety and feasibility protocol approved by the Institution Research and Ethics Committee. No atrial fibrillation procedures were included in this protocol. All patients gave informed consent.
1. Description of the Robotic Magnetic Navigation System
The Catheter Guidance Control and Imaging (CGCI) system employs eight powerful electromagnets to produce a highly agile magnetic field (to 0.16 Tesla) within an effective control area optimized to focus and contain the magnetic field almost entirely within the magnetic chamber. The magnetic chamber operates silently, has no moving parts and cools the electromagnet coils with non-toxic mineral oil. Current-regulated amplifiers provide the power to the magnetic chamber coils. The system produces magnetic fields 10 to 20 times less in intensity than Magnetic Resonance Imaging and no magnetic fields are generated when it is not in magnetic guidance mode. The magnetic field generators provide torque and force for moving, positioning and directing the tip of a catheter equipped with three permanent magnet pellets attached to its distal end.
The Robotic system includes an Operation Console, the CGCI Controller computer and a motorized linear catheter advancement mechanism. The system uses a standard 3-axis joystick, which is used to rotate the magnetic field and manually advance or retract the catheter. A 3D Controller is used to push the catheter in any screen-oriented direction. The X-Ray C-Arm may be rotated or extracted at the Operation Console using the X-Ray Dialog. The Operation Console unifies the display of the CGCI system, electroanatomical mapping system, EP recording system, intracardiac ultrasound (ICE), and X-Ray. It allows the direct keyboard and mouse control over the electroanatomical mapping system and EP recording system. Typically, the center screen is used for the electroanatomical mapping system screen and the CGCI overlay graphics.
2. Patient’s Preparation
Admit the patient to the hospital the same day or the day before the procedure. Overnight fasting state is required.
3. Conventional Electrophysiological Study
4. Preparing for Remote Navigation. Catheter, Sheath, and Catheter Advancement Mechanism Assembly
5. Remote Navigation and Mapping
6. Ablation. Manual and Automated Catheter Positioning in the Target Sites
The safety of the CGCI system is evaluated for each one of the experimental steps.
This new remote magnetic navigation system allows real-time remote catheter navigation inside the right and left atrial chambers, either in the operator or automated mode. The latter is obtained after almost instantaneous field vector adjustments of direction and intensity of torque, bending, rotating, and field gradient for axial push-pull movement (See video for illustration).
The system allows arrhythmia termination upon radiofrequency delivery in the absence of major complications (cardiac tamponade, pulmonary embolism or major hemorrhages) during this initial ablation experience (Figure 4).
The automated catheter remote navigation is highly reproducible, accurate, and rapid to position and keeps the catheter tip on the desired target. Based on five initial experimental procedures the navigation was 95.7 % reproducible, the average accuracy was 1.9±0.9 mm and the average time to reach the target was 23.28±14.8 sec. We considered nine targets in the right atrium (coronary sinus, 2 locations at the high right atrium, 3 locations at the tricuspid annulus, His, superior vena cava and inferior vena cava), nine targets in the left atrium (2 locations at the left atrial appendage, 3 locations at the mitral annulus and one location at each one of the pulmonary veins), six target sites in the right ventricle (2 locations at the right ventricular outflow tract, apex, right ventricle free wall, inferior wall and septum) and five more targets in the left ventricle (apex, anterior wall, lateral wall, septum and left ventricular outflow tract). Neither time, accuracy nor reproducibility to reach a target site were significantly different between chambers and targets.
Type of Arrhythmia | Atrial Substrate | Type of ablation | Acute Success | Procedure-derived Complications*** | Recurrences |
LA flutter (n=3) | Right PVs | Posterior wall line | Yes | None | No. 6 months FU |
Left PVs | Roof line | Yes* | None | No. 4 months FU | |
Inferior lateral wall | Focal RF delivery | Yes** | None | No. 3 months FU | |
RA flutter (N=2) | Counterclockwise cavo-tricuspidIsthmus dependent RA flutter | Cavo-tricuspidIsthmus line | Yes | None | No. 10 months FU |
Yes | None | No. 11 months FU |
Table 1. Atrial substrates and ablation results using the CGCI system. FU: follow up. LA: left atrium. RF: radiofrequency. RA: right atrium. PV: pulmonary vein.*Induction of 2 more non sustained and non clinical LA flutter morphologies.**LA flutter no longer re-inducible. Induction of atrial fibrillation at the end of the study.***The presence of pericardial effusion was assessed by intracardiac echocardiography throughout the procedure.
Figure 1. Agilis ES sheath (A) and MedFact magnetized and irrigated gold tip catheter (B) used for geometrical reconstruction and ablation in the right and left atrial chambers.
Figure 2. Components for remote navigation. A, motorized linear catheter advancement mechanism with a sterilizable wheel drive gearbox and a motor base. It includes a disposable sheath clip and leg mount. The magnetized catheter is inserted into the sheath and manually advanced into the right/left atrium. B, right hand 3D Controller used to steer the catheter to specific sites within the atrial chambers by changing the direction of the magnetic field. C, left hand 3-axis joystick to control the amount of catheter slack.
Figure 3. 3D electro-anatomical mapping geometry of the left atrium and pulmonary veins. A, geometrical point acquisitions within the left atrium using the magnetized catheter, which is represented with the white tip and the overlaying yellow arrow. The magnetic icon displays the coil power values as colors: green indicates a strong positive field, and red indicates a strong negative field. In blue a catheter into the coronary sinus. In red a screw-in catheter positioned in the right atrial septum. The multipolar catheter is shown in yellow. B, final view of the 3D anatomical reconstruction of the left atrium. MA; mitral annulus.
Figure 4. Interruption of a left atrial flutter circuit around the right pulmonary veins after automatically guided radiofrequency energy delivered to specific sites in the posterior wall of the left atrium. A, voltage map shows a dense scar in the posterior wall of the left atrium (grey color). B, first post-pacing interval map generated to characterize the reentrant circuit, which is localized around the right pulmonary veins (posterior view is shown). White and red indicate first post-pacing intervals <30 msec. C and D, in automated mode the catheter is driven to the target points and the arrhythmia terminates after completing a line in the posterior wall of the left atrium, which interrupts the reentrant circuit. Click here to view larger figure.
This is the first clinical report using the CGCI remote navigation system. It shows important technical features that might facilitate both navigation and ablation in right and left atrial substrates. The system may potentially overcome some of the limitations of the former magnetic-based Niobe system.10 Thus, endocardial contact force and navigation inside the cardiac chambers may substantially improve by increasing the strength of the magnetic field magnitude up to 0.16 Tesla compared with 0.08 Tesla in the Niobe system. Continuous and rapid shaping and reshaping of the magnetic field, rather than moving external magnets to change the magnetic field,13,14 provides instantaneously transmitted changes to the tip of the magnetized catheter leading to almost real‐time remote navigation. In automated mode the CGCI system also provides a true closed-loop servo system that has the ability to keep the catheter tip on a desired anatomic target by continuously adjusting the direction and intensity of the magnetic fields.17
The Sensei system, based on steerable sheaths manipulated within the heart by a mechanical robotic arm, allows real-time catheter movements.12 However, the use of mechanical forces to drive the catheter does not represent a technological advance over manual manipulation. Initial reports using the Sensei system had raised the concern of higher rate of cardiac tamponade than conventional manual radiofrequency delivery,18,19 which might have been related to remote manipulation of the stiff steerable Artisan catheter (Hansen Medical, Mountain View, CA, USA). Further experience and introduction of a special feature of the system to indirectly estimate catheter contact force on the tissue (IntelliSense) have shown that tamponade rates are not superior to conventional manual approach and may be more related to different temperature and power radiofrequency settings.20
The CGCI system does not require a lab with specific magnetic isolation since the magnetic field is highly focused on patient’s torso. In addition, the electrophysiology room can be used either as a conventional electrophysiology lab or as a magnetic lab by moving patient’s table from its regular position towards the magnetic chamber. The latter can be done either manually or by remote control. Although no major complications have been present in this initial experience, in case of serious complications, such as pericardial effusion and tamponade, it would be possible to remove the patient from the magnetic chamber in ≈15 sec.
General demerits such as lack of real-time contact force monitoring or lesion visualization still apply to the CGCI system. Combining robotic navigation with real-time contact force catheters and direct visualization of the atrial cavities may be a future feasible approach to increase long-term success of ablation lesions and decrease the risk of complications. To date, experimental data using the CGCI system in pigs have demonstrated reproducible navigation and accurate and rapid catheter positioning on the selected ablation targets within the atrial chambers.17 Once the ablation target is localized, the system has the ability to navigate the catheter tip to the selected target despite the cardiac motion and anatomical irregularities. Furthermore, necropsy studies in the same animals revealed that the majority of radiofrequency lesions were transmural.17 In this first report in humans the system also shows reproducible navigation and accurate and rapid catheter positioning on the selected ablation targets within the right or left atrial chambers. The use of rapid magnetic field adjustments might enhance catheter tip stability and result in fewer radiofrequency applications as well as fewer major complications. Although the results and follow up in this initial experience are encouraging, future large and randomized clinical trials in patients undergoing complex catheter-guided ablation procedures are needed to demonstrate these potential benefits.
The authors have nothing to disclose.
Supported in part by Magnetecs Inc. (Inglewood, California, USA) in collaboration with the Comunidad de Madrid and La Paz University Hospital. We thank Iván Filgueiras-Rama and Jaime Palomo-Cousido for their help in the illustration of the figures and video editing.
Name of Reagent/ Equipment | Company | Catalog Number | Comments |
Radiofocus Introducer II 7 Fr. | Terumo | RS*R70N10MQ | |
Radiofocus Introducer II 6 Fr. | Terumo | RS*R60N10MQ | |
Avanti+ Introducer 9 Fr. | Cordis, Johnson & Johnson | 504-609X | |
Pecutaneous Transeptal Catheter Introducer Set 8 Fr. | Medtronic | 008591 | |
Brockenbrough Curved Needle | Medtronic | 003994 | |
Percutaneuos Transeptal Catheter Introducer Agilis ES | St. Jude Medical | 3271521 | |
BRK Transeptal Curved Needle | St. Jude Medical | 407205; | |
Extension Set | Sendal | L-303/100 | |
Extension Tube (25 cm) | Iberhospitex S.A | 0044402 | |
BD Eclipse Needle 25G x 5/8 (0.5 mm x 16 mm) | BD | 305760 | |
BD Eclipse Needle 21G x 1 1/2 TW (0.8 mm x 40 mm) | BD | 305895 | |
Surgical Gloves Sterile | Semperit Technische Produkte Gesellschaft m. b. H. Division Sempermed | 826054720 | |
Adult Cannula with 2.1 m Tubing | Wolfram Droh GmbH | MDRNC-03N | |
Oxygen Mask | Carburos Medica Grupo Air Products | 75098 | |
Saline | Baxter S.L. | PE1324 | |
Saline | Laboratorios Grifols | 3033986 | |
Sterile Disposable Scalpel | Sovereign | D16390 | |
I.V. Set for Gravity Infusion | Sendal | NT-820-ELL180 | |
Sterile Banded Bag | Barrier | 705845 | |
Sterile Gauzes | Ortopedia y Cirugía, S.L. | 0323 | |
Sterile Syringe | BD Plastipak | 302188 | |
Infusion Set. Anti-Siphon Valve 15 μm Filter | Alaris | 273-002 | |
Infusion Pump (x4) | CardinalHealth | 25042ESD1 | |
Povidone-iodine (antiseptic for topical application) | Lainco, S.A. | 619791.2 EFP | |
Morfine Hydrochloride 1% | B. Braun | 451062 | |
Propofol | Fresenius Kani | 600514 | |
Heparin | Hospira Productos Farmacéuticos y Hospitalarios, S.L. | Q63004 | |
Lidocaine 1% | B. Braun | 645598 | |
Midazolam | B. Braun | 602567 | |
Iodixanol Injection 320 mgI/mL | GE Healthcare | 687251.2 | |
Pre-gelled Electrosurgical Plate | Blayco | 2125-5 | |
Single Patient Use ECG Electrodes | Ambu | SP-00-S/50 | |
Irrigated Magnetic Navigation Catheter MagnoFlush Gold Tip 4 mm. | MedFact Engineering GmbH | 100-002 | |
Screw-in Catheter. Temporary Transcenous Pacing Lead System | Medtronic | 6416-200 | |
Extension Cable | Medtronic | 9670560 | |
Extension Cable (Number of pins 10) (x2) | Bard Electrophysiology | 560004A | |
Extension Cable (Number of pins 4) | Bard Electrophysiology | 560002P | |
Extension Cable | St. Jude Medical | ESI-42-04644-001 | |
Extension Cable | St. Jude Medical | SJM 100011418 | |
Connection Cable from IBI-Generator to MedFact RF-Ablation Catheter | MedFact Engineering GmbH | 100-013 | |
Decapolar Catheter Bard Viking 6F Josephson 115 cm | Bard Electrophysiology | 400034 | |
Multipolar (24 poles) Woven Diagnostic Electrode Catheter | Bard Electrophysiology | 6FMC00798 | |
Ensite NavX System (Version 8.1) | St. Jude Medical | 100022310 | |
Ensite System Patient Interface Unit | St. Jude Medical | 75-05049-001 | |
Ensite NavX Surface Electrode Kit | St. Jude Medical | EN0010-002 | |
Irrigation Qiona Pump | MollerMedical GmbH. Biotronik SE & Co. | 363270 | |
External Defibrillator/Monitor LifePaK12 | Medtronic | 073-20719-10 | |
X-Ray C-Arm Ziehm Vision2 FD Vario | Ziehm Imaging | TS04_001a | |
Cardiac Ablation Generator. Software Version V3.0 | Irvine Biomedical, Inc. A St. Jude Medical Company | IBI-1500T11 | |
IBI-1500T11 Remote Control | Irvine Biomedical, Inc. A St. Jude Medical Company | 85524 | |
Dispersive Electrode Filter | St. Jude Medical | 3183417 | |
Stimulus Generator Unit for EPS 320 Cardiac Stimulator Models | Micropace Pty. Ltd. | MP3008 | |
Lab System Pro EP Recording System | Bard Electrophysiology | The system includes several components provided by the company | |
NEC Multisync LCD Screen | Micropace Pty. Ltd. | 3892D240 | |
Whole Blood Microcoagulation System. Hemochron Jr. | International Technidyne Corporation (ITC) | HJ7023 | |
Cuvettes for ACT for performance on the Hemochron | International Technidyne Corporation (ITC) | FB5033 | |
Ultrasound Catheter ViewFlex PLUS 9 Fr. | St. Jude Medical | VF-PM | |
ViewFlex Catheter Interface Module | St. Jude Medical | 20-1783-0000 | |
HD11 Digital Ultrasound Machine | Philips | US30975460 | |
CGCI, Magnetic Navigation System, Catheter Guidance, Control and Imaging System | Magnetecs Corporation | The system includes several components provided by the company. Further support and information may be obtained at:
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