4.11:
Therapeutic Index
The therapeutic index of a drug is the ratio of the dose that is toxic in 50% of the population to the dose that is effective in 50%.
The therapeutic index of a drug provides a range of effective and toxic doses.
An anticoagulant agent like warfarin has a narrow therapeutic index window for achieving the desired anticoagulation effect. However, within the effective dose range, some individuals may experience hemorrhage due to the overlapping toxic dose.
Drugs with a large therapeutic index value are considered safe since their effective and toxic concentrations are farther apart.
For such drugs, a dose higher than the minimum required to achieve the desired effect may be administered.
In summary, although a high therapeutic index may indicate relative safety, a smaller margin suggests potential toxic effects. The therapeutic index, as an indicator of a drug’s safety, has limitations since the data relies on animal toxicity studies, which may not precisely reflect the toxic effects experienced in humans.
4.11:
Therapeutic Index
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to achieve the desired anticoagulation effect. However, within this range of effective doses, individuals may experience adverse reactions such as hemorrhage due to the toxic dose overlapping with the effective dose. Medications with a high therapeutic index value are generally deemed safe because there is a larger gap between their effective and toxic concentrations. For these types of drugs, it is acceptable to administer a dose that surpasses the minimum required dose to achieve the intended therapeutic effect.
In conclusion, while a high therapeutic index can indicate the relative safety of a drug, a smaller margin between effective and toxic doses suggests potential toxic effects. It is important to remember that the therapeutic index, a measure of a drug's safety, has certain limitations because the data used to calculate the therapeutic index often relies on animal toxicity studies. These studies may not always accurately reflect the toxic effects experienced in humans.