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Chapter 1

Pharmacokinetics and Pharmacodynamics: Introduction

Drugs come in various dosage forms, including solids, liquids, semisolids, or aerosols. These formulations deliver drugs at the site of action, triggering …
Pharmacokinetic models use mathematical analysis to express a drug's time course in the body. These models can simulate rates of a drug's …
Plasma drug levels, plotted at regular intervals, help track its time course in the body. For instance, consider a plot after a single oral dose. The drug …
Drug concentration represents the drug amount present in a biological sample. It helps assess the initial drug pharmacokinetics in the body. The samples …
Pharmacokinetic models view drugs within the body as dynamic entities and rely on calculus as a vital tool for quantitative drug movement analysis. …
Mathematical expressions help understand pharmacokinetic parameters by using equations to describe the relationships between different variables. For …
Pharmacokinetic models incorporate reaction order and rate to comprehend processes such as drug absorption and elimination. In pharmacokinetics, the rate …
Traditional pharmacokinetic methods involve taking multiple samples from a few individuals and estimating pharmacokinetic parameters. Despite their common …
Pharmacodynamics is the scientific study that explores the biochemical, cellular, and physiological effects of drugs on the body. Most drug effects result …
Drug design involves discovering new medications based on specific biological targets. It relies on structure-activity relationships, SAR, or quantitative …
Administration of drugs can lead to either agonist or antagonist effect. Agonism occurs when a drug activates a receptor, triggering a biological …
Drug control governance involves global regulatory bodies that standardize and control the safety and efficacy of pharmaceuticals, as well as prevent …
The recently introduced microphysiological systems (MPS) cultivating human organoids are expected to perform better than animals in the preclinical tests …
Hyperlipidemia has become a leading risk factor for cardiovascular diseases and liver injury worldwide. Fructus Phyllanthi (FP) is an effective drug …
Dry powder inhalers offer numerous advantages for delivering drugs to the lungs, including stable solid-state drug formulations, device portability, bolus …