Adapting Microrespirometry for Drosophila - Insights into CASK Mutant Metabolism

Coulometric respirometry is ideal for measuring the metabolic rate of small organisms. When adapted for Drosophila melanogaster in the present study, measured O₂ consumption was within the range reported for wildtype D. melanogaster by previous studies. Per-fly O₂ consumption by CASK mutants, which are smaller and less active, was significantly lower than the wildtype.