1Department of Neurological Surgery,University of California, San Francisco, 2Weill Institute for Neurosciences,University of California, San Francisco, 3Department of Psychiatry and Behavioral Sciences,University of California, San Francisco, 4Department of Neurology,University of California, San Francisco
Summary
Deep brain stimulation triggered by a patient-specific neural biomarker of a high-symptom state may better control symptoms of major depressive disorder compared to continuous, open-loop stimulation. This protocol provides a workflow for identifying a patient-specific neural biomarker and controlling the delivery of therapeutic stimulation based on the identified biomarker.
