Yu-Hua Tseng Section on Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center Harvard Medical School Biography Publications Institution JoVE Articles Yu-Hua Tseng has not added a biography. If you are Yu-Hua Tseng and would like to personalize this page please email our Author Liaison for assistance. Publications Adipose Tissue in Communication: Within and Without Nature Reviews. Endocrinology. Feb, 2023 | Pubmed ID: 36526875 Aberrant Expression of Agouti Signaling Protein (ASIP) As a Cause of Monogenic Severe Childhood Obesity Nature Metabolism. Dec, 2022 | Pubmed ID: 36536132 ADRA1A-Gα Signalling Potentiates Adipocyte Thermogenesis Through CKB and TNAP Nature Metabolism. Nov, 2022 | Pubmed ID: 36344764 Architecture of the Outbred Brown Fat Proteome Defines Regulators of Metabolic Physiology Cell. Nov, 2022 | Pubmed ID: 36334589 Phosphatase Protector Alpha4 (α4) is Involved in Adipocyte Maintenance and Mitochondrial Homeostasis Through Regulation of Insulin Signaling Nature Communications. Oct, 2022 | Pubmed ID: 36241662 Brown Adipose Tissue-derived MaR2 Contributes to Cold-induced Resolution of Inflammation Nature Metabolism. Jun, 2022 | Pubmed ID: 35760872 Silk Hydrogel-Mediated Delivery of Bone Morphogenetic Protein 7 Directly to Subcutaneous White Adipose Tissue Increases Browning and Energy Expenditure Frontiers in Bioengineering and Biotechnology. 2022 | Pubmed ID: 35646839 Endothelial Cells Induced Progenitors Into Brown Fat to Reduce Atherosclerosis Circulation Research. Jul, 2022 | Pubmed ID: 35642564 Transplantation of Brown Adipose Tissue with the Ability of Converting Omega-6 to Omega-3 Polyunsaturated Fatty Acids Counteracts High-Fat-Induced Metabolic Abnormalities in Mice International Journal of Molecular Sciences. May, 2022 | Pubmed ID: 35628137 Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells Stem Cells (Dayton, Ohio). 03, 2022 | Pubmed ID: 35511869 Ejection of Damaged Mitochondria and Their Removal by Macrophages Ensure Efficient Thermogenesis in Brown Adipose Tissue Cell Metabolism. Apr, 2022 | Pubmed ID: 35305295 Signaling Lipidomic Analysis of Thermogenic Adipocytes Methods in Molecular Biology (Clifton, N.J.). 2022 | Pubmed ID: 35167102 Characterization of Transcript Enrichment and Detection Bias in Single-nucleus RNA-seq for Mapping of Distinct Human Adipocyte Lineages Genome Research. Feb, 2022 | Pubmed ID: 35042723 The Evolving View of Thermogenic Adipocytes - Ontogeny, Niche and Function Nature Reviews. Endocrinology. Dec, 2021 | Pubmed ID: 34625737 N-butylidenephthalide Ameliorates High-fat Diet-induced Obesity in Mice and Promotes Browning Through Adrenergic Response/AMPK Activation in Mouse Beige Adipocytes Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. Dec, 2021 | Pubmed ID: 34487913 β3-Adrenergic Receptors Regulate Human Brown/beige Adipocyte Lipolysis and Thermogenesis JCI Insight. Jun, 2021 | Pubmed ID: 34100382 Narrating the Story ARC of Adipose Tissue Aging Developmental Cell. May, 2021 | Pubmed ID: 34004148 Cold-induction of Afadin in Brown Fat Supports Its Thermogenic Capacity Scientific Reports. May, 2021 | Pubmed ID: 33963248 Challenges in Tackling Energy Expenditure As Obesity Therapy: From Preclinical Models to Clinical Application Molecular Metabolism. Sep, 2021 | Pubmed ID: 33878401 Defining the Lineage of Thermogenic Perivascular Adipose Tissue Nature Metabolism. Apr, 2021 | Pubmed ID: 33846639 Vascular Smooth Muscle-derived Trpv1 Progenitors Are a Source of Cold-induced Thermogenic Adipocytes Nature Metabolism. Apr, 2021 | Pubmed ID: 33846638 Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution Cell Reports. Jan, 2021 | Pubmed ID: 33440156 Adipocyte Microenvironment: Everybody in the Neighborhood Talks About the Temperature Cell Metabolism. Jan, 2021 | Pubmed ID: 33406404 Brown Fat-Activating Lipokine 12,13-diHOME in Human Milk Is Associated With Infant Adiposity The Journal of Clinical Endocrinology and Metabolism. Jan, 2021 | Pubmed ID: 33135728 The Involvement of Neuroimmune Cells in Adipose Innervation Molecular Medicine (Cambridge, Mass.). 12, 2020 | Pubmed ID: 33297933 CRISPR-engineered Human Brown-like Adipocytes Prevent Diet-induced Obesity and Ameliorate Metabolic Syndrome in Mice Science Translational Medicine. Aug, 2020 | Pubmed ID: 32848096 Lipidomics of Brown and White Adipose Tissue: Implications for Energy Metabolism Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. Oct, 2020 | Pubmed ID: 32763428 The Link Between Stress and IL-6 Is Heating Up Cell Metabolism. Aug, 2020 | Pubmed ID: 32755607 The Heating Microenvironment: Intercellular Cross Talk Within Thermogenic Adipose Tissue Diabetes. Aug, 2020 | Pubmed ID: 32690661 Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells Cell. Aug, 2020 | Pubmed ID: 32679029 Integrated Metabolomics Reveals Altered Lipid Metabolism in Adipose Tissue in a Model of Extreme Longevity GeroScience. Dec, 2020 | Pubmed ID: 32632845 Commentary On: "The Presence of Active Brown Adipose Tissue Determines Cold-Induced Energy Expenditure and Oxylipin Profiles in Humans" The Journal of Clinical Endocrinology and Metabolism. Aug, 2020 | Pubmed ID: 32559764 The Perlman Syndrome DIS3L2 Exoribonuclease Safeguards Endoplasmic Reticulum-targeted MRNA Translation and Calcium Ion Homeostasis Nature Communications. May, 2020 | Pubmed ID: 32457326 Single-cell Transcriptional Networks in Differentiating Preadipocytes Suggest Drivers Associated with Tissue Heterogeneity Nature Communications. Apr, 2020 | Pubmed ID: 32355218 Parental Metabolic Syndrome Epigenetically Reprograms Offspring Hepatic Lipid Metabolism in Mice The Journal of Clinical Investigation. May, 2020 | Pubmed ID: 32250344 Analyzing Mitochondrial Function in Brown Adipocytes with a Bioenergetic Analyzer Methods in Molecular Biology (Clifton, N.J.). 2020 | Pubmed ID: 32219757 FGF6 and FGF9 Regulate UCP1 Expression Independent of Brown Adipogenesis Nature Communications. Mar, 2020 | Pubmed ID: 32184391 Cell-autonomous Light Sensitivity Via Opsin3 Regulates Fuel Utilization in Brown Adipocytes PLoS Biology. Feb, 2020 | Pubmed ID: 32040503 Lipokines and Thermogenesis Endocrinology. Oct, 2019 | Pubmed ID: 31504387 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat Cell Metabolism. Oct, 2019 | Pubmed ID: 31353262 Afadin is a Scaffold Protein Repressing Insulin Action Via HDAC6 in Adipose Tissue EMBO Reports. Aug, 2019 | Pubmed ID: 31264358 ComBATing Aging-does Increased Brown Adipose Tissue Activity Confer Longevity? GeroScience. Jun, 2019 | Pubmed ID: 31230192 TGF-β2 is an Exercise-induced Adipokine That Regulates Glucose and Fatty Acid Metabolism Nature Metabolism. Feb, 2019 | Pubmed ID: 31032475 Insulin Receptor-mediated Signaling Regulates Pluripotency Markers and Lineage Differentiation Molecular Metabolism. 12, 2018 | Pubmed ID: 30316806 Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism Cell Reports. Jul, 2018 | Pubmed ID: 30021173 RGB-Color Intensiometric Indicators to Visualize Spatiotemporal Dynamics of ATP in Single Cells Angewandte Chemie (International Ed. in English). Aug, 2018 | Pubmed ID: 29952110 Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis Cell Metabolism. Jul, 2018 | Pubmed ID: 29861389 12,13-diHOME: An Exercise-Induced Lipokine That Increases Skeletal Muscle Fatty Acid Uptake Cell Metabolism. May, 2018 | Pubmed ID: 29719226 Adapted MS/MS Shotgun Lipidomics Approach for Analysis of Cardiolipin Molecular Species Lipids. Jan, 2018 | Pubmed ID: 29488636 Brown Adipose Tissue Thermogenic Adaptation Requires Nrf1-mediated Proteasomal Activity Nature Medicine. Mar, 2018 | Pubmed ID: 29400713 Deciphering Adipose Tissue Heterogeneity Annals of the New York Academy of Sciences. Jan, 2018 | Pubmed ID: 28763833 Integrating Extracellular Flux Measurements and Genome-Scale Modeling Reveals Differences Between Brown and White Adipocytes Cell Reports. Dec, 2017 | Pubmed ID: 29241534 Reestablishment of Energy Balance in a Male Mouse Model With POMC Neuron Deletion of BMPR1A Endocrinology. 12, 2017 | Pubmed ID: 29040444 MicroRNA Regulation of Brown Adipogenesis and Thermogenic Energy Expenditure Frontiers in Endocrinology. 2017 | Pubmed ID: 28878735 NFIA Co-localizes with PPARγ and Transcriptionally Controls the Brown Fat Gene Program Nature Cell Biology. Sep, 2017 | Pubmed ID: 28812581 Ca-associated Triphasic PH Changes in Mitochondria During Brown Adipocyte Activation Molecular Metabolism. Aug, 2017 | Pubmed ID: 28752044 Identification and Characterization of a Supraclavicular Brown Adipose Tissue in Mice JCI Insight. Jun, 2017 | Pubmed ID: 28570265 Optical Visualisation of Thermogenesis in Stimulated Single-cell Brown Adipocytes Scientific Reports. May, 2017 | Pubmed ID: 28469146 The Cold-induced Lipokine 12,13-diHOME Promotes Fatty Acid Transport into Brown Adipose Tissue Nature Medicine. May, 2017 | Pubmed ID: 28346411 Protocols for Generation of Immortalized Human Brown and White Preadipocyte Cell Lines Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28244042 Shades of Brown: an Introduction for the Special Focus Issue of Adipocyte on "brown and Beige/brite Adipocytes" Adipocyte. Apr, 2016 | Pubmed ID: 30168365 Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals Cell Metabolism. 09, 2016 | Pubmed ID: 27626200 Monoacylglycerol Analysis Using MS/MS(ALL) Quadruple Time of Flight Mass Spectrometry Metabolites. Aug, 2016 | Pubmed ID: 27548241 Loss of BMP Receptor Type 1A in Murine Adipose Tissue Attenuates Age-related Onset of Insulin Resistance Diabetologia. Aug, 2016 | Pubmed ID: 27209464 Tribbles 3 Inhibits Brown Adipocyte Differentiation and Function by Suppressing Insulin Signaling Biochemical and Biophysical Research Communications. Feb, 2016 | Pubmed ID: 26801556 3D Brown Adipogenesis to Create "Brown-Fat-in-Microstrands" Biomaterials. Jan, 2016 | Pubmed ID: 26496384 The Thermogenic Circuit: Regulators of Thermogenic Competency and Differentiation Genes & Diseases. Jun, 2015 | Pubmed ID: 26491708 MicroRNA-455 Regulates Brown Adipogenesis Via a Novel HIF1an-AMPK-PGC1α Signaling Network EMBO Reports. Oct, 2015 | Pubmed ID: 26303948 Curcumin Analogues As Selective Fluorescence Imaging Probes for Brown Adipose Tissue and Monitoring Browning Scientific Reports. Aug, 2015 | Pubmed ID: 26269357 Clonal Analyses and Gene Profiling Identify Genetic Biomarkers of the Thermogenic Potential of Human Brown and White Preadipocytes Nature Medicine. Jul, 2015 | Pubmed ID: 26076036 Genetic and Functional Characterization of Clonally Derived Adult Human Brown Adipocytes Nature Medicine. Apr, 2015 | Pubmed ID: 25774848 Disruption of Insulin Signaling in Myf5-expressing Progenitors Leads to Marked Paucity of Brown Fat but Normal Muscle Development Endocrinology. May, 2015 | Pubmed ID: 25625589 A Novel Role for Subcutaneous Adipose Tissue in Exercise-induced Improvements in Glucose Homeostasis Diabetes. Jun, 2015 | Pubmed ID: 25605808 Unwiring the Transcriptional Heat Circuit Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014 | Pubmed ID: 25261553 ASC-1, PAT2, and P2RX5 Are Cell Surface Markers for White, Beige, and Brown Adipocytes Science Translational Medicine. Jul, 2014 | Pubmed ID: 25080478 IRF4 is a Key Thermogenic Transcriptional Partner of PGC-1α Cell. Jul, 2014 | Pubmed ID: 24995979 Isolation of Progenitors That Exhibit Myogenic/osteogenic Bipotency in Vitro by Fluorescence-activated Cell Sorting from Human Fetal Muscle Stem Cell Reports. Jan, 2014 | Pubmed ID: 24678452 Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells Via a BMP4-NFATc1-thrombospondin-1 Axis Cell. Jan, 2014 | Pubmed ID: 24485453 Glial Cell Line-derived Neurotrophic Factor Protects Against High-fat Diet-induced Obesity American Journal of Physiology. Gastrointestinal and Liver Physiology. Mar, 2014 | Pubmed ID: 24458024 Brown Fat Fuel Utilization and Thermogenesis Trends in Endocrinology and Metabolism: TEM. Apr, 2014 | Pubmed ID: 24389130 Systemic Control of Brown Fat Thermogenesis: Integration of Peripheral and Central Signals Annals of the New York Academy of Sciences. Oct, 2013 | Pubmed ID: 24111913 Quantification of Human and Rodent Brown Adipose Tissue Function Using 99mTc-methoxyisobutylisonitrile SPECT/CT and 18F-FDG PET/CT Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Nov, 2013 | Pubmed ID: 24071505 Brown Adipose Tissue: Development, Metabolism and Beyond The Biochemical Journal. Jul, 2013 | Pubmed ID: 23805974 Anatomical Localization, Gene Expression Profiling and Functional Characterization of Adult Human Neck Brown Fat Nature Medicine. May, 2013 | Pubmed ID: 23603815 Anti-melanin-concentrating Hormone Treatment Attenuates Chronic Experimental Colitis and Fibrosis American Journal of Physiology. Gastrointestinal and Liver Physiology. May, 2013 | Pubmed ID: 23538494 Brown-fat Paucity Due to Impaired BMP Signalling Induces Compensatory Browning of White Fat Nature. Mar, 2013 | Pubmed ID: 23485971 Ablation of TRIP-Br2, a Regulator of Fat Lipolysis, Thermogenesis and Oxidative Metabolism, Prevents Diet-induced Obesity and Insulin Resistance Nature Medicine. Feb, 2013 | Pubmed ID: 23291629 P62 Links β-adrenergic Input to Mitochondrial Function and Thermogenesis The Journal of Clinical Investigation. Jan, 2013 | Pubmed ID: 23257354 Brown Adipose Tissue Regulates Glucose Homeostasis and Insulin Sensitivity The Journal of Clinical Investigation. Jan, 2013 | Pubmed ID: 23221344 Increased Mitochondrial Activity in BMP7-treated Brown Adipocytes, Due to Increased CPT1- and CD36-mediated Fatty Acid Uptake Antioxidants & Redox Signaling. Jul, 2013 | Pubmed ID: 22938691 Brown Adipose Tissue: Recent Insights into Development, Metabolic Function and Therapeutic Potential Adipocyte. Jan, 2012 | Pubmed ID: 23700507 Intrinsic Differences in Adipocyte Precursor Cells from Different White Fat Depots Diabetes. Jul, 2012 | Pubmed ID: 22596050 Bone Morphogenetic Protein 7 (BMP7) Reverses Obesity and Regulates Appetite Through a Central MTOR Pathway FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2012 | Pubmed ID: 22331196 Necdin Controls Proliferation of White Adipocyte Progenitor Cells PloS One. 2012 | Pubmed ID: 22292082 Insulin/IGF-I Regulation of Necdin and Brown Adipocyte Differentiation Via CREB- and FoxO1-associated Pathways Endocrinology. Oct, 2011 | Pubmed ID: 21862615 Genetic and Evolutionary Analyses of the Human Bone Morphogenetic Protein Receptor 2 (BMPR2) in the Pathophysiology of Obesity PloS One. Feb, 2011 | Pubmed ID: 21311592 Identification of Inducible Brown Adipocyte Progenitors Residing in Skeletal Muscle and White Fat Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011 | Pubmed ID: 21173238 Cross Talk Between Insulin and Bone Morphogenetic Protein Signaling Systems in Brown Adipogenesis Molecular and Cellular Biology. Sep, 2010 | Pubmed ID: 20584981 Cellular Bioenergetics As a Target for Obesity Therapy Nature Reviews. Drug Discovery. Jun, 2010 | Pubmed ID: 20514071 Insulin and Insulin-like Growth Factor-1 Receptors Act As Ligand-specific Amplitude Modulators of a Common Pathway Regulating Gene Transcription The Journal of Biological Chemistry. May, 2010 | Pubmed ID: 20360006 Emerging Role of Bone Morphogenetic Proteins in Adipogenesis and Energy Metabolism Cytokine & Growth Factor Reviews. 2009 | Pubmed ID: 19896888 Adipose Tissue Expression and Genetic Variants of the Bone Morphogenetic Protein Receptor 1A Gene (BMPR1A) Are Associated with Human Obesity Diabetes. Sep, 2009 | Pubmed ID: 19502417 Identification and Importance of Brown Adipose Tissue in Adult Humans The New England Journal of Medicine. Apr, 2009 | Pubmed ID: 19357406 New Role of Bone Morphogenetic Protein 7 in Brown Adipogenesis and Energy Expenditure Nature. Aug, 2008 | Pubmed ID: 18719589 Sostanza P Come Destinazione Di Romanzo Anti-obesità Gastroenterology. Mar, 2008 | Pubmed ID: 18325388 Dissection of the Insulin Signaling Pathway Via Quantitative Phosphoproteomics Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18268350 Rad GTPase Deficiency Leads to Cardiac Hypertrophy Circulation. Dec, 2007 | Pubmed ID: 18056528 Developmental Origin of Fat: Tracking Obesity to Its Source Cell. Oct, 2007 | Pubmed ID: 17956727 Loss of ARNT/HIF1beta Mediates Altered Gene Expression and Pancreatic-islet Dysfunction in Human Type 2 Diabetes Cell. Aug, 2005 | Pubmed ID: 16096055 Previsione Di Differenziazione Preadipocyte Di Espressione Del Gene Rivela Il Ruolo Dei Substrati Del Recettore Insulina E Necdin Nature Cell Biology. Jun, 2005 | Pubmed ID: 15895078 Central Role of Suppressors of Cytokine Signaling Proteins in Hepatic Steatosis, Insulin Resistance, and the Metabolic Syndrome in the Mouse Proceedings of the National Academy of Sciences of the United States of America. Jul, 2004 | Pubmed ID: 15240880 Differential Roles of Insulin Receptor Substrates in Brown Adipocyte Differentiation Molecular and Cellular Biology. Mar, 2004 | Pubmed ID: 14966273 Differential Roles of Insulin Receptor Substrates in the Anti-apoptotic Function of Insulin-like Growth Factor-1 and Insulin The Journal of Biological Chemistry. Aug, 2002 | Pubmed ID: 12082100 Molecular Balance Between the Regulatory and Catalytic Subunits of Phosphoinositide 3-kinase Regulates Cell Signaling and Survival Molecular and Cellular Biology. Feb, 2002 | Pubmed ID: 11784871 Interaction of the Ras-related Protein Associated with Diabetes Rad and the Putative Tumor Metastasis Suppressor NM23 Provides a Novel Mechanism of GTPase Regulation Proceedings of the National Academy of Sciences of the United States of America. Dec, 1999 | Pubmed ID: 10611312 Generazione di topi knockout specifici per il grasso bruno utilizzando un sistema combinato di RNA a guida singola Cre-LoxP, CRISPR-Cas9 e virus adeno-associato Tadataka Tsuji1, Yang Zhang1, Yu-Hua Tseng1 1Section on Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School JoVE 65083 Biologia
Generazione di topi knockout specifici per il grasso bruno utilizzando un sistema combinato di RNA a guida singola Cre-LoxP, CRISPR-Cas9 e virus adeno-associato Tadataka Tsuji1, Yang Zhang1, Yu-Hua Tseng1 1Section on Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School JoVE 65083 Biologia