John W.R. Schwabe

Publications

• Histone Deacetylase (HDAC) 1 and 2 Are Essential for Accurate Cell Division and the Pluripotency of Embryonic Stem Cells
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014  |   Pubmed ID: 24958871
• The Ansamycin Antibiotic, Rifamycin SV, Inhibits BCL6 Transcriptional Repression and Forms a Complex with the BCL6-BTB/POZ Domain
  PloS One. 2014  |   Pubmed ID: 24595451
• An Evolving Understanding of Nuclear Receptor Coregulator Proteins
  Journal of Molecular Endocrinology. Dec, 2013  |   Pubmed ID: 24203923
• Mzt1/Tam4, a Fission Yeast MOZART1 Homologue, is an Essential Component of the γ-tubulin Complex and Directly Interacts with GCP3(Alp6)
  Molecular Biology of the Cell. Nov, 2013  |   Pubmed ID: 24006493
• Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates
  Molecular Cell. Jul, 2013  |   Pubmed ID: 23791785
• A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death
  Molecular Cell. Jul, 2012  |   Pubmed ID: 22683266
• Structure of HDAC3 Bound to Co-repressor and Inositol Tetraphosphate
  Nature. Jan, 2012  |   Pubmed ID: 22230954
• A Mutation in the Thyroid Hormone Receptor Alpha Gene
  The New England Journal of Medicine. Jan, 2012  |   Pubmed ID: 22168587
• Nuclear Hormone Receptor Co-repressors: Structure and Function
  Molecular and Cellular Endocrinology. Jan, 2012  |   Pubmed ID: 21925568
• FERM-dependent E3 Ligase Recognition is a Conserved Mechanism for Targeted Degradation of Lipoprotein Receptors
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011  |   Pubmed ID: 22109552
• The IDOL-UBE2D Complex Mediates Sterol-dependent Degradation of the LDL Receptor
  Genes & Development. Jun, 2011  |   Pubmed ID: 21685362
• Structural Basis for the Assembly of the SMRT/NCoR Core Transcriptional Repression Machinery
  Nature Structural & Molecular Biology. Feb, 2011  |   Pubmed ID: 21240272
• Negative Regulation by Nuclear Receptors: a Plethora of Mechanisms
  Trends in Endocrinology and Metabolism: TEM. Mar, 2011  |   Pubmed ID: 21196123
• Comparison of the Molecular Consequences of Different Mutations at Residue 754 and 690 of the Androgen Receptor (AR) and Androgen Insensitivity Syndrome (AIS) Phenotype
  Clinical Endocrinology. Aug, 2009  |   Pubmed ID: 19178528
• Structural Basis for the Activation of PPARgamma by Oxidized Fatty Acids
  Nature Structural & Molecular Biology. Sep, 2008  |   Pubmed ID: 19172745
• Structural Insights into the Interaction and Activation of Histone Deacetylase 3 by Nuclear Receptor Corepressors
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2005  |   Pubmed ID: 15837933
• Identification of a Novel Co-regulator Interaction Surface on the Ligand Binding Domain of Nurr1 Using NMR Footprinting
  The Journal of Biological Chemistry. Dec, 2004  |   Pubmed ID: 15456745
• Mechanism of the Nuclear Receptor Molecular Switch
  Trends in Biochemical Sciences. Jun, 2004  |   Pubmed ID: 15276186
• Nuclear Receptors: the Evolution of Diversity
  Science's STKE : Signal Transduction Knowledge Environment. Jan, 2004  |   Pubmed ID: 14747695
• Tyrosine Agonists Reverse the Molecular Defects Associated with Dominant-negative Mutations in Human Peroxisome Proliferator-activated Receptor Gamma
  Endocrinology. Apr, 2004  |   Pubmed ID: 14657011
• Molecular Determinants of the Balance Between Co-repressor and Co-activator Recruitment to the Retinoic Acid Receptor
  The Journal of Biological Chemistry. Oct, 2003  |   Pubmed ID: 12917445
• A Conserved Structural Motif Reveals the Essential Transcriptional Repression Function of Spen Proteins and Their Role in Developmental Signaling
  Genes & Development. Aug, 2003  |   Pubmed ID: 12897056
• A Dynamic Mechanism of Nuclear Receptor Activation and Its Perturbation in a Human Disease
  Nature Structural Biology. Feb, 2003  |   Pubmed ID: 12536206
• The Structural Basis for the Specificity of Retinoid-X Receptor-selective Agonists: New Insights into the Role of Helix H12
  The Journal of Biological Chemistry. Mar, 2002  |   Pubmed ID: 11782480