Jean Rommelaere Tumour Virology Division F010 German Cancer Research Center (DKFZ) Biography Publications Institution JoVE Articles Jean Rommelaere has not added a biography. If you are Jean Rommelaere and would like to personalize this page please email our Author Liaison for assistance. Publications Phase I/IIa Study of Intratumoral/intracerebral or Intravenous/intracerebral Administration of Parvovirus H-1 (ParvOryx) in Patients with Progressive Primary or Recurrent Glioblastoma Multiforme: ParvOryx01 Protocol BMC Cancer. Mar, 2012 | Pubmed ID: 22436661 Activation of a Helper and Not Regulatory Human CD4+ T Cell Response by Oncolytic H-1 Parvovirus PloS One. 2012 | Pubmed ID: 22359669 Retargeting of Rat Parvovirus H-1PV to Cancer Cells Through Genetic Engineering of the Viral Capsid Journal of Virology. Apr, 2012 | Pubmed ID: 22258256 Activation of the Human Immune System by Chemotherapeutic or Targeted Agents Combined with the Oncolytic Parvovirus H-1 BMC Cancer. 2011 | Pubmed ID: 22029859 Interferon γ Improves the Vaccination Potential of Oncolytic Parvovirus H-1PV for the Treatment of Peritoneal Carcinomatosis in Pancreatic Cancer Cancer Biology & Therapy. Nov, 2011 | Pubmed ID: 22024742 Regression of Glioma in Rat Models by Intranasal Application of Parvovirus H-1 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2011 | Pubmed ID: 21715567 The Combined Effects of Oncolytic Reovirus Plus Newcastle Disease Virus and Reovirus Plus Parvovirus on U87 and U373 Cells In vitro and In vivo Journal of Neuro-oncology. Sep, 2011 | Pubmed ID: 21607667 Immune Cells Participate in the Oncosuppressive Activity of Parvovirus H-1PV and Are Activated As a Result of Their Abortive Infection with This Agent Cancer Biology & Therapy. Jan, 2011 | Pubmed ID: 21124075 Enhancement of NK Cell Antitumor Responses Using an Oncolytic Parvovirus International Journal of Cancer. Journal International Du Cancer. Feb, 2011 | Pubmed ID: 20473905 Therapeutic Implications of the Enhanced Short and Long-term Cytotoxicity of Radiation Treatment Followed by Oncolytic Parvovirus H-1 Infection in High-grade Glioma Cells Bioengineered Bugs. Nov-Dec, 2010 | Pubmed ID: 21468212 Sodium Butyrate with UCN-01 Has Marked Antitumour Activity Against Cervical Cancer Cells Anticancer Research. Oct, 2010 | Pubmed ID: 21036719 Through Its Nonstructural Protein NS1, Parvovirus H-1 Induces Apoptosis Via Accumulation of Reactive Oxygen Species Journal of Virology. Jun, 2010 | Pubmed ID: 20375165 Regression of Advanced Rat and Human Gliomas by Local or Systemic Treatment with Oncolytic Parvovirus H-1 in Rat Models Neuro-oncology. Aug, 2010 | Pubmed ID: 20299703 Improved Killing of Human High-grade Glioma Cells by Combining Ionizing Radiation with Oncolytic Parvovirus H-1 Infection Journal of Biomedicine & Biotechnology. 2010 | Pubmed ID: 20224643 Oncolytic Parvoviruses As Cancer Therapeutics Cytokine & Growth Factor Reviews. Apr-Jun, 2010 | Pubmed ID: 20211577 Parvovirus H1 Selectively Induces Cytotoxic Effects on Human Neuroblastoma Cells International Journal of Cancer. Journal International Du Cancer. Sep, 2010 | Pubmed ID: 20087864 Activation of an Antiviral Response in Normal but Not Transformed Mouse Cells: a New Determinant of Minute Virus of Mice Oncotropism Journal of Virology. Jan, 2010 | Pubmed ID: 19864388 SMAD4: a Predictive Marker of PDAC Cell Permissiveness for Oncolytic Infection with Parvovirus H-1PV International Journal of Cancer. Journal International Du Cancer. Jun, 2010 | Pubmed ID: 19856310 Oncolytic Rat Parvovirus H-1PV, a Candidate for the Treatment of Human Lymphoma: In Vitro and in Vivo Studies Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2009 | Pubmed ID: 19367260 Ezrin-radixin-moesin Family Proteins Are Involved in Parvovirus Replication and Spreading Journal of Virology. Jun, 2009 | Pubmed ID: 19321616 Improvement of Gemcitabine-based Therapy of Pancreatic Carcinoma by Means of Oncolytic Parvovirus H-1PV Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2009 | Pubmed ID: 19147756 Biophysical and Biochemical Characterization of a Liposarcoma-derived Recombinant MnSOD Protein Acting As an Anticancer Agent International Journal of Cancer. Journal International Du Cancer. Dec, 2008 | Pubmed ID: 18798256 Viral Proteins Killing Tumor Cells: New Weapons in the Fight Against Cancer Cancer Biology & Therapy. Sep, 2008 | Pubmed ID: 18769128 Vesicular Egress of Non-enveloped Lytic Parvoviruses Depends on Gelsolin Functioning PLoS Pathogens. 2008 | Pubmed ID: 18704167 Killing of P53-deficient Hepatoma Cells by Parvovirus H-1 and Chemotherapeutics Requires Promyelocytic Leukemia Protein World Journal of Gastroenterology : WJG. Jun, 2008 | Pubmed ID: 18609705 Arming Parvoviruses with CpG Motifs to Improve Their Oncosuppressive Capacity International Journal of Cancer. Journal International Du Cancer. Jun, 2008 | Pubmed ID: 18360875 Parvovirus Interference with Intracellular Signalling: Mechanism of PKCeta Activation in MVM-infected A9 Fibroblasts Cellular Microbiology. Mar, 2008 | Pubmed ID: 18042254 A Viral Adaptor Protein Modulating Casein Kinase II Activity Induces Cytopathic Effects in Permissive Cells Proceedings of the National Academy of Sciences of the United States of America. Jul, 2007 | Pubmed ID: 17636126 Combined Oncolytic and Vaccination Activities of Parvovirus H-1 in a Metastatic Tumor Model Oncology Reports. Jun, 2007 | Pubmed ID: 17487410 Cytosolic Activation of Cathepsins Mediates Parvovirus H-1-induced Killing of Cisplatin and TRAIL-resistant Glioma Cells Journal of Virology. Apr, 2007 | Pubmed ID: 17287256 MCP-3 (CCL7) Delivered by Parvovirus MVMp Reduces Tumorigenicity of Mouse Melanoma Cells Through Activation of T Lymphocytes and NK Cells International Journal of Cancer. Journal International Du Cancer. Mar, 2007 | Pubmed ID: 17154174 Humoral Immune Responses Against Minute Virus of Mice Vectors The Journal of Gene Medicine. Sep, 2006 | Pubmed ID: 16800041 Human SGT Interacts with Bag-6/Bat-3/Scythe and Cells with Reduced Levels of Either Protein Display Persistence of Few Misaligned Chromosomes and Mitotic Arrest Experimental Cell Research. Aug, 2006 | Pubmed ID: 16777091 Oncolytic Murine Autonomous Parvovirus, a Candidate Vector for Glioma Gene Therapy, is Innocuous to Normal and Immunocompetent Mouse Glial Cells Cell and Tissue Research. Sep, 2006 | Pubmed ID: 16699801 NS1 Interaction with CKII Alpha: Novel Protein Complex Mediating Parvovirus-induced Cytotoxicity Journal of Virology. May, 2006 | Pubmed ID: 16641266 Tumor Suppressive Activity of a Variant Isoform of Manganese Superoxide Dismutase Released by a Human Liposarcoma Cell Line International Journal of Cancer. Journal International Du Cancer. Aug, 2006 | Pubmed ID: 16550599 Phosphorylation on Ser106 Modulates the Cellular Functions of the SHOX Homeodomain Protein Journal of Molecular Biology. Jan, 2006 | Pubmed ID: 16325853 Parvovirus H-1-induced Tumor Cell Death Enhances Human Immune Response in Vitro Via Increased Phagocytosis, Maturation, and Cross-presentation by Dendritic Cells Human Gene Therapy. Aug, 2005 | Pubmed ID: 16076257 Changes in Gene Expression Profiles Induced by Parvovirus H-1 in Human Gastric Cancer Cells Chinese Journal of Digestive Diseases. 2005 | Pubmed ID: 15904425 B1 Lymphocytes and Myeloid Dendritic Cells in Lymphoid Organs Are Preferential Extratumoral Sites of Parvovirus Minute Virus of Mice Prototype Strain Expression Journal of Virology. Mar, 2005 | Pubmed ID: 15731246 Expression Profiling of Human Hepatoma Cells Reveals Global Repression of Genes Involved in Cell Proliferation, Growth, and Apoptosis Upon Infection with Parvovirus H-1 Journal of Virology. Feb, 2005 | Pubmed ID: 15681429 The Infectivity and Lytic Activity of Minute Virus of Mice Wild-type and Derived Vector Particles Are Strikingly Different Journal of Virology. Jan, 2005 | Pubmed ID: 15596824 Selective Alterations of the Host Cell Architecture Upon Infection with Parvovirus Minute Virus of Mice Virology. Jan, 2005 | Pubmed ID: 15582663 Cancer Gene Therapy Through Autonomous Parvovirus--mediated Gene Transfer Current Gene Therapy. Sep, 2004 | Pubmed ID: 15384939 Carrier Cell-mediated Delivery of Oncolytic Parvoviruses for Targeting Metastases International Journal of Cancer. Journal International Du Cancer. May, 2004 | Pubmed ID: 14999784 Vectors Based on Autonomous Parvoviruses: Novel Tools to Treat Cancer? The Journal of Gene Medicine. Feb, 2004 | Pubmed ID: 14978762 Parvovirus H-1 Infection of Human Glioma Cells Leads to Complete Viral Replication and Efficient Cell Killing International Journal of Cancer. Journal International Du Cancer. Mar, 2004 | Pubmed ID: 14735471 The Human Small Glutamine-rich TPR-containing Protein is Required for Progress Through Cell Division Experimental Cell Research. Feb, 2004 | Pubmed ID: 14729056 Modulation of Minute Virus of Mice Cytotoxic Activities Through Site-directed Mutagenesis Within the NS Coding Region Journal of Virology. Dec, 2003 | Pubmed ID: 14610171 Oncolytic Parvovirus H1 Induces Release of Heat-shock Protein HSP72 in Susceptible Human Tumor Cells but May Not Affect Primary Immune Cells Cancer Gene Therapy. Jun, 2003 | Pubmed ID: 12768193 Chimeric and Pseudotyped Parvoviruses Minimize the Contamination of Recombinant Stocks with Replication-competent Viruses and Identify a DNA Sequence That Restricts Parvovirus H-1 in Mouse Cells Journal of Virology. Mar, 2003 | Pubmed ID: 12610161 Regulation of Minute Virus of Mice NS1 Replicative Functions by Atypical PKClambda in Vivo Journal of Virology. Jan, 2003 | Pubmed ID: 12477848 Production of Recombinant H1 Parvovirus Stocks Devoid of Replication-competent Viruses Human Gene Therapy. Dec, 2002 | Pubmed ID: 12542845 The NS2 Proteins of Parvovirus Minute Virus of Mice Are Required for Efficient Nuclear Egress of Progeny Virions in Mouse Cells Journal of Virology. Oct, 2002 | Pubmed ID: 12239307 Specific Interaction of the Nonstructural Protein NS1 of Minute Virus of Mice (MVM) with [ACCA](2) Motifs in the Centre of the Right-end MVM DNA Palindrome Induces Hairpin-primed Viral DNA Replication The Journal of General Virology. Jul, 2002 | Pubmed ID: 12075084 Suppression of Metastatic Hemangiosarcoma by a Parvovirus MVMp Vector Transducing the IP-10 Chemokine into Immunocompetent Mice Cancer Gene Therapy. May, 2002 | Pubmed ID: 11961666 Efficient Recombinant Parvovirus Production with the Help of Adenovirus-derived Systems Nazim El-Andaloussi*1,2, Barbara Leuchs*1, Serena Bonifati1,2, Jean Rommelaere1,2, Antonio Marchini1,2 1Tumour Virology Division F010, German Cancer Research Center (DKFZ), 2Inserm Unit 701, German Cancer Research Center (DKFZ) JoVE 3518 Imunologia e Infecção
Efficient Recombinant Parvovirus Production with the Help of Adenovirus-derived Systems Nazim El-Andaloussi*1,2, Barbara Leuchs*1, Serena Bonifati1,2, Jean Rommelaere1,2, Antonio Marchini1,2 1Tumour Virology Division F010, German Cancer Research Center (DKFZ), 2Inserm Unit 701, German Cancer Research Center (DKFZ) JoVE 3518 Imunologia e Infecção