Balamurali K. Ambati Department of Ophthalmology & Visual Sciences University of Utah Biography Publications Institution JoVE Articles Balamurali K. Ambati has not added a biography. If you are Balamurali K. Ambati and would like to personalize this page please email our Author Liaison for assistance. Publications Neurodegeneration Severity is Anticipated by Early Microglia Alterations Monitored in Vivo in a Mouse Model of Chronic Glaucoma Disease Models & Mechanisms. Mar, 2015 | Pubmed ID: 25755083 In vivo ZW800-microbead Imaging of Retinal and Choroidal Vascular Leakage in Mice Experimental Eye Research. May, 2015 | Pubmed ID: 25536533 AAV2 Delivery of Flt23k Intraceptors Inhibits Murine Choroidal Neovascularization Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2015 | Pubmed ID: 25306972 The Reduction of Serum Soluble Flt-1 in Patients with Neovascular Age-related Macular Degeneration American Journal of Ophthalmology. Jan, 2015 | Pubmed ID: 25284761 Morpholino-Mediated Isoform Modulation of Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) Reduces Colon Cancer Xenograft Growth Cancers. 2014 | Pubmed ID: 25534570 Trimanual Anterior Vitrectomy: A Novel Technique to Manage Vitreous Loss During Phacoemulsification Case Reports in Ophthalmology. Sep, 2014 | Pubmed ID: 25520653 IL-18 is Not Therapeutic for Neovascular Age-related Macular Degeneration Nature Medicine. Dec, 2014 | Pubmed ID: 25473914 DICER1/Alu RNA Dysmetabolism Induces Caspase-8-mediated Cell Death in Age-related Macular Degeneration Proceedings of the National Academy of Sciences of the United States of America. Nov, 2014 | Pubmed ID: 25349431 Endometrial VEGF Induces Placental SFLT1 and Leads to Pregnancy Complications The Journal of Clinical Investigation. Nov, 2014 | Pubmed ID: 25329693 Gender-based Salary Disparities: It Pays to Take a Closer Look Academic Medicine : Journal of the Association of American Medical Colleges. Aug, 2014 | Pubmed ID: 25072451 Spectacle Independence After Cataract Extraction in Post-Radial Keratotomy Patients Using Hybrid Monovision with ReSTOR(®) Multifocal and TECNIS(®) Monofocal Intraocular Lenses Case Reports in Ophthalmology. May, 2014 | Pubmed ID: 24987365 Pharmacokinetics and Efficacy of Bioerodible Dexamethasone Implant in Concanavalin A-induced Uveitic Cataract Rabbit Model Pharmaceutical Research. Nov, 2014 | Pubmed ID: 24947436 Vimentin Knockdown Decreases Corneal Opacity Investigative Ophthalmology & Visual Science. Jul, 2014 | Pubmed ID: 24854859 Angiographic Features of Transgenic Mice with Increased Expression of Human Serine Protease HTRA1 in Retinal Pigment Epithelium Investigative Ophthalmology & Visual Science. Jun, 2014 | Pubmed ID: 24854852 FLT1 Genetic Variation Predisposes to Neovascular AMD in Ethnically Diverse Populations and Alters Systemic FLT1 Expression Investigative Ophthalmology & Visual Science. Jun, 2014 | Pubmed ID: 24812550 Dry Eye Predisposes to Corneal Neovascularization and Lymphangiogenesis After Corneal Injury in a Murine Model Cornea. Jun, 2014 | Pubmed ID: 24727637 Rejuvenating Clinician-scientist Training Investigative Ophthalmology & Visual Science. Mar, 2014 | Pubmed ID: 24681976 Acridine Orange Leukocyte Fluorography in Mice Experimental Eye Research. Mar, 2014 | Pubmed ID: 24333760 Presurgical Corticosteroid Treatment Improves Corneal Transplant Survival in Mice Cornea. Dec, 2013 | Pubmed ID: 24005616 Minus Piggyback Lens Overlaying ReSTOR(®) Multifocal Lens in High Myopia Case Reports in Ophthalmology. May, 2013 | Pubmed ID: 23898294 Photoreceptor Avascular Privilege is Shielded by Soluble VEGF Receptor-1 ELife. 2013 | Pubmed ID: 23795287 Soluble Vascular Endothelial Growth Factor Receptor 3 is Essential for Corneal Alymphaticity Blood. May, 2013 | Pubmed ID: 23476047 Targeted Intraceptor Nanoparticle Therapy Reduces Angiogenesis and Fibrosis in Primate and Murine Macular Degeneration ACS Nano. Apr, 2013 | Pubmed ID: 23464925 Development of a Novel Bioerodible Dexamethasone Implant for Uveitis and Postoperative Cataract Inflammation Journal of Controlled Release : Official Journal of the Controlled Release Society. Apr, 2013 | Pubmed ID: 23321274 Dual Suppression of Hemangiogenesis and Lymphangiogenesis by Splice-shifting Morpholinos Targeting Vascular Endothelial Growth Factor Receptor 2 (KDR) FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2013 | Pubmed ID: 22997228 Ocular Drug Delivery for Glaucoma Management Pharmaceutics. 2012 | Pubmed ID: 24300188 ERK1/2 Activation is a Therapeutic Target in Age-related Macular Degeneration Proceedings of the National Academy of Sciences of the United States of America. Aug, 2012 | Pubmed ID: 22869729 Effect of Glucocorticoid (triamcinolone Acetonide) Pretreatment in a Murine Penetrating Keratoplasty and Suture Model Cornea. Dec, 2012 | Pubmed ID: 22677639 DICER1 Loss and Alu RNA Induce Age-related Macular Degeneration Via the NLRP3 Inflammasome and MyD88 Cell. May, 2012 | Pubmed ID: 22541070 Nanoparticle-mediated Delivery of ShRNA.VEGF-a Plasmids Regresses Corneal Neovascularization Investigative Ophthalmology & Visual Science. May, 2012 | Pubmed ID: 22467572 Morpholino-mediated Increase in Soluble Flt-1 Expression Results in Decreased Ocular and Tumor Neovascularization PloS One. 2012 | Pubmed ID: 22438952 Flt23k Nanoparticles Offer Additive Benefit in Graft Survival and Anti-angiogenic Effects when Combined with Triamcinolone Investigative Ophthalmology & Visual Science. Apr, 2012 | Pubmed ID: 22427553 Vascular Endothelial Growth Factor Receptor 1 Morpholino Decreases Angiogenesis in a Murine Corneal Suture Model Investigative Ophthalmology & Visual Science. Feb, 2012 | Pubmed ID: 22199251 Anterior Chamber Intraocular Lens, Sutured Posterior Chamber Intraocular Lens, or Glued Intraocular Lens: Where Do We Stand? Current Opinion in Ophthalmology. Jan, 2012 | Pubmed ID: 22081029 Short-interfering RNAs Induce Retinal Degeneration Via TLR3 and IRF3 Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2012 | Pubmed ID: 21988875 Tarantula Hairs As Corneal Foreign Bodies Case Reports in Ophthalmology. Sep, 2011 | Pubmed ID: 22125534 Horizons in Therapy for Corneal Angiogenesis Ophthalmology. Mar, 2011 | Pubmed ID: 21376242 Endocapsular Carousel Technique Phacoemulsification Journal of Cataract and Refractive Surgery. Mar, 2011 | Pubmed ID: 21333865 DICER1 Deficit Induces Alu RNA Toxicity in Age-related Macular Degeneration Nature. Mar, 2011 | Pubmed ID: 21297615 Whirlin Replacement Restores the Formation of the USH2 Protein Complex in Whirlin Knockout Photoreceptors Investigative Ophthalmology & Visual Science. Apr, 2011 | Pubmed ID: 21212183 Gene Delivery Nanoparticles Fabricated by Supercritical Fluid Extraction of Emulsions International Journal of Pharmaceutics. Mar, 2010 | Pubmed ID: 20025945 Anti-SPARC Oligopeptide Inhibits Laser-induced CNV in Mice Vision Research. Mar, 2010 | Pubmed ID: 20005890 The Capsule Drug Device: Novel Approach for Drug Delivery to the Eye Vision Research. Mar, 2010 | Pubmed ID: 19854210 Corneal Transparency: Genesis, Maintenance and Dysfunction Brain Research Bulletin. Feb, 2010 | Pubmed ID: 19481138 Mediators of Ocular Angiogenesis Journal of Genetics. Dec, 2009 | Pubmed ID: 20090210 Targeted Drug and Gene Delivery Systems for Lung Cancer Therapy Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2009 | Pubmed ID: 19920099 Alternatively Spliced Vascular Endothelial Growth Factor Receptor-2 is an Essential Endogenous Inhibitor of Lymphatic Vessel Growth Nature Medicine. Sep, 2009 | Pubmed ID: 19668192 Surface-functionalized Nanoparticles for Targeted Gene Delivery Across Nasal Respiratory Epithelium FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2009 | Pubmed ID: 19608628 CCR3 is a Target for Age-related Macular Degeneration Diagnosis and Therapy Nature. Jul, 2009 | Pubmed ID: 19525930 Small Interfering RNA-induced TLR3 Activation Inhibits Blood and Lymphatic Vessel Growth Proceedings of the National Academy of Sciences of the United States of America. Apr, 2009 | Pubmed ID: 19359485 Corneal Stroma PDGF Blockade and Myofibroblast Development Experimental Eye Research. May, 2009 | Pubmed ID: 19133260 Sequence- and Target-independent Angiogenesis Suppression by SiRNA Via TLR3 Nature. Apr, 2008 | Pubmed ID: 18368052 Molecular Docking and Analysis of Interactions Between Vascular Endothelial Growth Factor (VEGF) and SPARC Protein Journal of Molecular Graphics & Modelling. Nov, 2007 | Pubmed ID: 17560152 Nanoparticles Sustain Expression of Flt Intraceptors in the Cornea and Inhibit Injury-induced Corneal Angiogenesis Investigative Ophthalmology & Visual Science. May, 2007 | Pubmed ID: 17460257 Unique Homologous SiRNA Blocks Hypoxia-induced VEGF Upregulation in Human Corneal Cells and Inhibits and Regresses Murine Corneal Neovascularization Cornea. Jan, 2007 | Pubmed ID: 17198016 Soluble Vascular Endothelial Growth Factor Receptor-1 Contributes to the Corneal Antiangiogenic Barrier The British Journal of Ophthalmology. Apr, 2007 | Pubmed ID: 17151056 Flt-1 Intraceptor Induces the Unfolded Protein Response, Apoptotic Factors, and Regression of Murine Injury-induced Corneal Neovascularization Investigative Ophthalmology & Visual Science. Nov, 2006 | Pubmed ID: 17065489 Corneal Avascularity is Due to Soluble VEGF Receptor-1 Nature. Oct, 2006 | Pubmed ID: 17051153 Loss of SPARC-mediated VEGFR-1 Suppression After Injury Reveals a Novel Antiangiogenic Activity of VEGF-A The Journal of Clinical Investigation. Feb, 2006 | Pubmed ID: 16453023 Drusen Complement Components C3a and C5a Promote Choroidal Neovascularization Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006 | Pubmed ID: 16452172 Eyelid Disease Ophthalmology. Nov, 2005 | Pubmed ID: 16271321 Systemic Soluble Tie2 Expression Inhibits and Regresses Corneal Neovascularization Biochemical and Biophysical Research Communications. Jun, 2005 | Pubmed ID: 15896317 Flt-1 Intraceptors Inhibit Hypoxia-induced VEGF Expression in Vitro and Corneal Neovascularization in Vivo Investigative Ophthalmology & Visual Science. May, 2005 | Pubmed ID: 15851564 Quality of Vision and Patient Satisfaction After LASIK Current Opinion in Ophthalmology. Aug, 2004 | Pubmed ID: 15232473 Aquaporin-1 Expression is Decreased in Human and Mouse Corneal Endothelial Dysfunction Molecular Vision. Jan, 2004 | Pubmed ID: 14758337 An Animal Model of Age-related Macular Degeneration in Senescent Ccl-2- or Ccr-2-deficient Mice Nature Medicine. Nov, 2003 | Pubmed ID: 14566334 Macrophage Depletion Inhibits Experimental Choroidal Neovascularization Investigative Ophthalmology & Visual Science. Aug, 2003 | Pubmed ID: 12882810 Inhibition of Corneal Neovascularization by Genetic Ablation of CCR2 Cornea. Jul, 2003 | Pubmed ID: 12827053 Targeted Disruption of the CD18 or ICAM-1 Gene Inhibits Choroidal Neovascularization Investigative Ophthalmology & Visual Science. Jun, 2003 | Pubmed ID: 12766082 Age-related Macular Degeneration: Etiology, Pathogenesis, and Therapeutic Strategies Survey of Ophthalmology. May-Jun, 2003 | Pubmed ID: 12745003 Sustained Inhibition of Corneal Neovascularization by Genetic Ablation of CCR5 Investigative Ophthalmology & Visual Science. Feb, 2003 | Pubmed ID: 12556387 Angiostatin Inhibits and Regresses Corneal Neovascularization Archives of Ophthalmology (Chicago, Ill. : 1960). Aug, 2002 | Pubmed ID: 12149060 Age-related Eye Disease Study Caveats Archives of Ophthalmology (Chicago, Ill. : 1960). Jul, 2002 | Pubmed ID: 12096983 In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma Alejandra Bosco1, Cesar O. Romero1, Balamurali K. Ambati2, Monica L. Vetter1 1Department of Neurobiology & Anatomy, University of Utah, 2Department of Ophthalmology & Visual Sciences, University of Utah JoVE 52731 Medicina
In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma Alejandra Bosco1, Cesar O. Romero1, Balamurali K. Ambati2, Monica L. Vetter1 1Department of Neurobiology & Anatomy, University of Utah, 2Department of Ophthalmology & Visual Sciences, University of Utah JoVE 52731 Medicina