JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다. 전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.
1Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin and Berlin Institute of Health Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, 2Chair for Medical Information Technology,RWTH Aachen University
Chapters
- 00:05Introduction
- 00:44The Mechanical Ventilation
- 01:46Introduction of the Pulmonary Artery Catheter
- 02:46Surfactant Depletion
- 03:41Injurious Ventilation with High Tidal Volume/Low PEEP (High Tv/low PEEP)
- 04:25Results: Effects of the Injurious Ventilation on the Lungs
- 05:40Conclusion
A combination of surfactant washout using 0.9% saline (35 mL/kg body weight, 37 °C) and high tidal volume ventilation with low PEEP to cause moderate ventilator induced lung injury (VILI) results in experimental acute respiratory distress syndrome (ARDS). This method provides a model of lung injury with low/limited recruitability to study the effect of various ventilation strategies for extended periods.
