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Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice
JoVE Journal
Behavior
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JoVE Journal Behavior
Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

English

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15,067 Views

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09:34 min

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June 19, 2019

DOI:

10.3791/59598-v

DOI:
10.3791/59598-v

•

09:34 min
June 19, 2019

•

12 Views
, , , , , ,
1Dept. of Stress Neurobiology and Neurogenetics,Max Planck Institute of Psychiatry, 2Graduate School of Systemic Neurosciences,Ludwig Maximilians University, 3Max Planck Florida Institute for Neuroscience, 4Dept. of Neurobiology,Weizmann Institute of Science

Summary

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This method describes a chronic preparation that allows optical access to the hippocampus of living mice. This preparation can be used to perform longitudinal optical imaging of neuronal structural plasticity and activity-evoked cellular plasticity over a period of several weeks.

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Cite this Article

Ulivi, A. F., Castello-Waldow, T. P., Weston, G., Yan, L., Yasuda, R., Chen, A., Attardo, A. Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice. J. Vis. Exp. (148), e59598, doi:10.3791/59598 (2019).

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