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High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
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Biology
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JoVE Journal Biology
High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)

English

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11,825 Views

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11:38 min

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May 10, 2016

DOI:

10.3791/53987-v

DOI:
10.3791/53987-v

•

11:38 min
May 10, 2016

•

4 Views
, , , , , , ,
1Biological System Research (BSR),Philip Morris International R&D

Summary

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The objective of the study was to assess the biological impact of 15 cigarette smoke constituents using a combination of an impedance-based real time cell analyzer and a high-content screening (HCS)-based platform for toxicological assessment in vitro. This study provides information on effective doses, toxicity and modes of action of the tested compounds.

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Marescotti, D., Gonzalez Suarez, I., Acali, S., Johne, S., Laurent, A., Frentzel, S., Hoeng, J., Peitsch, M. C. High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC). J. Vis. Exp. (111), e53987, doi:10.3791/53987 (2016).

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