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Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice
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JoVE Journal Behavior
Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice

Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice

English

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12,781 Views

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10:14 min

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March 30, 2016

DOI:

10.3791/53310-v

DOI:
10.3791/53310-v

•

10:14 min
March 30, 2016

•

3 Views
, ,
1Department of Physiology,Northwestern University

Summary

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The preparation presented here for whisker-signaled eyeblink conditioning in head-fixed mice precisely stimulates specific whiskers while allowing mice to ambulate on a cylindrical treadmill. A whisker stimulation conditioned stimulus (CS) paired with a periorbital shock unconditioned stimulus (US) results in reliable associative learning on this apparatus.

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Cite this Article

Lin, C., Disterhoft, J., Weiss, C. Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice. J. Vis. Exp. (109), e53310, doi:10.3791/53310 (2016).

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