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July 09, 2010
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High frequency Doppler ultrasound is a novel technology for assessing regional myocardial function. This work presents first evidence demonstrating applicability of this versatile imaging platform for the repeated measure of myocardial strain, dp/dt, and mitral regurgitation in the ischemia-reperfused (IR) murine heart.
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High-frequencyHigh-resolution EchocardiographyNon-invasiveRepeated MeasureMyocardial StrainContractilityMitral RegurgitationIschemia-reperfused Murine HeartSurgical ProcedureImagingTemporal ChangesFunctional ParametersClinical SignificanceTwo-dimensional MoviesFrame RateMyocardial ElastogramsStrain ProfilesQuantitative AssessmentLeft-ventricular ContractionLV RelaxationIsovolumetric PhasesPre-IR And Post-IR Beating HeartsIntact MiceCompromised Wall MotionAnatomical DeformationInfarcted MyocardiumInternal Diameters Of Mitral Valve Orifice And AortaEffective Regurgitant OrificeTurbulence In Blood Flow PatternColor Doppler MoviesVelocity ProfilesLV Sector Asynchrony
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Gnyawali, S. C., Roy, S., Driggs, J., Khanna, S., Ryan, T., Sen, C. K. High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart. J. Vis. Exp. (41), e1781, doi:10.3791/1781 (2010).
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