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In vivo Positron Emission Tomography to Reveal Activity Patterns Induced by Deep Brain Stimulation in Rats
1Centro Nacional de Investigaciones Cardiovasculares (CNIC), 2Laboratorio de Imagen Médica,Instituto de Investigación Sanitaria Gregorio Marañón, 3Departamento de Bioingeniería e Ingeniería Aeroespacial,Universidad Carlos III de Madrid, 4CIBER de Salud Mental (CIBERSAM), 5High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut),Universidad Rey Juan Carlos
章
- 00:04Introduction
- 00:50Brain Target Localization by In Vivo Neuroimaging
- 02:12Stereotaxic Surgery
- 05:56PET-CT Imaging Acquisition
- 06:46DBS Stimulator Configuration
- 07:30Results: Evaluating the Consequences of Deep Brain Stimulation via In Vivo Neuroimaging
- 08:46Conclusion
We describe a preclinical experimental method to evaluate metabolic neuromodulation induced by acute deep brain stimulation with in vivo FDG-PET. This manuscript includes all experimental steps, from stereotaxic surgery to the application of the stimulation treatment and the acquisition, processing, and analysis of PET images.
