Rodents are not able to report migraine symptoms. Here, we describe a manageable test paradigm (light/dark and open field assays) to measure light aversion, one of the most common and bothersome symptoms in patients with migraines.
Wang, M., Mason, B. N., Sowers, L. P., Kuburas, A., Rea, B. J., Russo, A. F. Investigating Migraine-Like Behavior Using Light Aversion in Mice. J. Vis. Exp. (174), e62839, doi:10.3791/62839 (2021).