ジャーナル

/

/

通过分子动力学模拟破译激活EGFR体电突变的结构效应

JoVE Journal
生化学

This content is Free Access.

JoVE Journal 生化学

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Please note that all translations are automatically generated. Click here for the English version.

通过分子动力学模拟破译激活EGFR体电突变的结构效应

8,004 Views

•

15:05 min

•

May 20, 2020

DOI:

10.3791/61125-v

DOI:

10.3791/61125-v

•

15:05 min

May 20, 2020

•

3 Views

Mahlet Z. Tamirat¹, Kari J. Kurppa², Klaus Elenius^2,3,4, Mark S. Johnson¹

¹Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering,Åbo Akademi University, ²Medicity Research Laboratories and Institute of Biomedicine,University of Turku, ³Turku Bioscience Centre,University of Turku and Åbo Akademi University, ⁴Department of Oncology and Radiotherapy,University of Turku and Turku University Hospital

概要

该协议的目的是利用分子动力学模拟来检查由于EGFR激酶蛋白的激活突变而发生的动态结构变化。

Explore More Videos

Molecular Dynamics Simulation EGFR Somatic Mutations Protein Structure Kinase Conformational Changes Ligand Binding Cancer Wild-type Deletion Mutant Active Inactive Asymmetric Dimer Kymera Protein Data Bank Modeling

Read Article