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Generación de fibrillas alfa-Synucleinas preformadas de monómeros y uso in vivo
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June 02, 2019
DOI:
1Department of Translational Science and Molecular Medicine,Michigan State University, 2The Michael J. Fox Foundation for Parkinson’s Research, 3Neuroscience Program,Michigan State University, 4Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine,University of Pennsylvania Perelman School of Medicine, 5Center for Neurodegeneration and Experimental Therapeutics,University of Alabama at Birmingham, 6Mercy Health Hauenstein Neuroscience Medical Center
概要
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El objetivo de este artículo es delinear los pasos requeridos para la generación de fibrillas a partir de alfa-synuclein monomérica, control de calidad subsiguiente y uso de las fibrillas preformadas in vivo.
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Patterson, J. R., Polinski, N. K., Duffy, M. F., Kemp, C. J., Luk, K. C., Volpicelli-Daley, L. A., Kanaan, N. M., Sortwell, C. E. Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo. J. Vis. Exp. (148), e59758, doi:10.3791/59758 (2019).
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