Neuronal excitability can be modulated through a dynamic process of endo- and exocytosis of excitatory ionotropic glutamate receptors. Described here is an accessible, high-content assay for quantifying surface and internal receptor population pools.
Ghane, M. A., Yakout, D. W., Mabb, A. M. A High-content Assay for Monitoring AMPA Receptor Trafficking. J. Vis. Exp. (143), e59048, doi:10.3791/59048 (2019).