Here we present a tail-tip blood sampling protocol for frequent sample collection in unrestrained mice. This method is useful for assessing patterns of pulsatile luteinizing hormone secretion and could be adapted for analysis of other circulating factors.
McCosh, R. B., Kreisman, M. J., Breen, K. M. Frequent Tail-tip Blood Sampling in Mice for the Assessment of Pulsatile Luteinizing Hormone Secretion. J. Vis. Exp. (137), e57894, doi:10.3791/57894 (2018).