The TreadWheel uses rotational motion to gently induce exercise in adult Drosophila melanogaster by exploiting flies' innate, negative geotaxis. It allows for analysis of the interactions between exercise and factors, such as genotype, sex, and diet, and their effect on physiological and molecular assays to assess metabolic health.
Lowman, K. E., Wyatt, B. J., Cunneely, O. P., Reed, L. K. The TreadWheel: Interval Training Protocol for Gently Induced Exercise in Drosophila melanogaster. J. Vis. Exp. (136), e57788, doi:10.3791/57788 (2018).