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Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
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January 26, 2018
DOI:
1Harris-Wellbeing Preterm Birth Research Centre, Department of Cellular and Molecular Physiology, Institute of Translational Medicine,University of Liverpool, 2School of Biomedical Sciences,The University of Queensland, 3Faculty of Chemistry, Institute of Biological Chemistry,University of Vienna, 4Institute for Molecular Bioscience,University of Queensland, 5Center for Physiology and Pharmacology,Medical University of Vienna
概要
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This article describes experimental protocols to study ex vivo contractions of human myometrium and their application in drug discovery. This technique is used to improve the understanding of myometrial physiology and pathophysiology as well as to validate pharmacological data from novel research probes or drug leads.
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Arrowsmith, S., Keov, P., Muttenthaler, M., Gruber, C. W. Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development. J. Vis. Exp. (131), e56639, doi:10.3791/56639 (2018).
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