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High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer’s Disease Gene Susceptibility Assessment
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July 18, 2017
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1Department of Immunology,Reims University Hospitals, Robert Debré Hospital, 2Faculty of Medicine, LRN EA 4682,University of Reims Champagne-Ardenne, 3Department of Internal Medicine and Geriatrics,Reims University Hospitals, Maison Blanche Hospital, 4Faculty of Medicine, EA 3797,University of Reims Champagne-Ardenne
概要
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Here, we describe an innovative method to determine complement receptor 1 (CR1) length polymorphisms for use in several applications, particularly the assessment of susceptibility to diseases such as Alzheimer's disease (AD). This method could be useful to better understand the role of CR1 isoforms in the pathogenesis of AD.
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Kisserli, A., Tabary, T., Cohen, J. H. M., Duret, V., Mahmoudi, R. High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment. J. Vis. Exp. (125), e56012, doi:10.3791/56012 (2017).
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