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A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
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January 02, 2017
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A method for establishing lung infections in immunocompetent rodents is described. With proficiency, this method can be performed quickly and easily to induce stable infection with many isolates of S. pneumoniae, H. influenzae, P. aeruginosa, K. pneumoniae and A. baumannii.
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Pneumonia ModelImmunocompetent RodentsAntibacterial EfficacyS. PneumoniaeH. InfluenzaeK. PneumoniaeP. AeruginosaA. BaumanniiIntrabronchial InfectionBacterial PneumoniaImmunocompetent ModelRobust And Reproducible Lung InfectionIntubationTracheaBacterial SuspensionAgar PlatesSalineSerial DilutionAgarWater BathIntubation Device
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Hoover, J. L., Lewandowski, T. F., Mininger, C. L., Singley, C. M., Sucoloski, S., Rittenhouse, S. A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii. J. Vis. Exp. (119), e55068, doi:10.3791/55068 (2017).
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