This manuscript describes several protocols for administering pharmacological agents to honey bees, including simple noninvasive methods for free-flying bees, as well as more invasive variants that allow precise localized treatment of restrained bees.
Søvik, E., Plath, J. A., Devaud, J., Barron, A. B. Neuropharmacological Manipulation of Restrained and Free-flying Honey Bees, Apis mellifera. J. Vis. Exp. (117), e54695, doi:10.3791/54695 (2016).