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Déplétion sélective des cellules microgliales du cervelet granules de cultures cellulaires utilisant la L-leucine Methyl Ester
JoVE Journal
神経科学
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JoVE Journal 神経科学
Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester

Déplétion sélective des cellules microgliales du cervelet granules de cultures cellulaires utilisant la L-leucine Methyl Ester

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08:10 min

July 07, 2015

DOI:

08:10 min
July 07, 2015

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概要

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Microglia can influence neurons and other glia in culture by various non-cell autonomous mechanisms. Here, we present a protocol to selectively deplete microglia from primary neuronal cultures. This method has the potential to elucidate the role of microglial-neuronal interactions, with implications for neurodegenerative conditions where neuroinflammation is a hallmark feature.

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