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An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
JoVE Journal
生物工学
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JoVE Journal 生物工学
An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

16,981 Views

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10:28 min

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June 07, 2015

DOI:

10.3791/52450-v

DOI:
10.3791/52450-v

•

10:28 min
June 07, 2015

•

6 Views
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1Institute for Complex Molecular Systems, Department of Biomedical Engineering, Laboratory of Chemical Biology,Eindhoven University of Technology, 2Department of Cardiology, Division Heart and Lungs, Interuniversity Cardiology Institute of the Netherlands (ICIN),University Medical Center Utrecht

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Supramolecular hydrogelators based on ureido-pyrimidinones allow full control over the macroscopic gel properties and the sol–gel switching behavior using pH. Here, we present a protocol for formulating and injecting such a supramolecular hydrogelator via a catheter delivery system for local delivery directly in relevant areas in the pig heart.

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Cite this Article

Pape, A. C. H., Bakker, M. H., Tseng, C. C. S., Bastings, M. M. C., Koudstaal, S., Agostoni, P., Chamuleau, S. A. J., Dankers, P. Y. W. An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart. J. Vis. Exp. (100), e52450, doi:10.3791/52450 (2015).

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