ジャーナル
/
免疫学と感染
/
Generazione di cellule CAR T per adottiva terapia nel contesto di Glioblastoma standard di cura
JoVE Journal
免疫学と感染
このコンテンツを視聴するには、JoVE 購読が必要です。  サインイン又は無料トライアルを申し込む。
JoVE Journal 免疫学と感染
Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
Please note that all translations are automatically generated. Click here for the English version.

Generazione di cellule CAR T per adottiva terapia nel contesto di Glioblastoma standard di cura

21,110 Views

•

12:55 min

•

February 16, 2015

DOI:

10.3791/52397-v

DOI:
10.3791/52397-v

•

12:55 min
February 16, 2015

•

4 Views
, , , , ,
1Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery,Duke University, 2Department of Biomedical Engineering,Duke University, 3病理学科,Duke University

概要

Automatically generated

The lymphodepletive and immunomodulatory effects of chemotherapy and radiation standard of care can be leveraged to enhance the antitumor efficacy of T cell immunotherapy. We outline a method for generating EGFRvIII-specific chimeric antigen receptor (CAR) T cells and administering them in the context of glioblastoma standard of care.

Explore More Videos

CAR T CellsAdoptive ImmunotherapyGlioblastomaEGFRvIIIStandard Of CareTemozolomideWhole Brain Irradiation

Read Article

Cite this Article

Riccione, K., Suryadevara, C. M., Snyder, D., Cui, X., Sampson, J. H., Sanchez-Perez, L. Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care. J. Vis. Exp. (96), e52397, doi:10.3791/52397 (2015).

Download .ris file

Copy

Share Video

.

Copy