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라운드 창 멤브레인을 통해 마우스 내부 귀에 바이러스로 매개 유전자 전달을위한 수술 방법
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JoVE Journal 神経科学
Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane
Please note that all translations are automatically generated. Click here for the English version.

라운드 창 멤브레인을 통해 마우스 내부 귀에 바이러스로 매개 유전자 전달을위한 수술 방법

14,807 Views

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07:32 min

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March 16, 2015

DOI:

10.3791/52187-v

DOI:
10.3791/52187-v

•

07:32 min
March 16, 2015

•

16 Views
, , ,
1Department of Otolaryngology-Head and Neck Surgery,University of California, San Francisco

概要

Automatically generated

The described post-auricular surgical approach allows rapid and direct delivery into the mouse cochlear scala tympani while minimizing blood loss and animal mortality. This method can be used for cochlear therapy using molecular, pharmacologic and viral delivery to postnatal mice through the round window membrane.

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Cite this Article

Akil, O., Rouse, S. L., Chan, D. K., Lustig, L. R. Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane. J. Vis. Exp. (97), e52187, doi:10.3791/52187 (2015).

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