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Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
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October 29, 2014
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Here, a procedure is described for the establishment of systemic infection in the neonatal rat with cultures of Escherichia coli K1. This non-invasive procedure permits colonization of the gastrointestinal tract, translocation of the pathogen to the systemic circulation, and invasion of the central nervous system at the choroid plexus.
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Dalgakiran, F., Witcomb, L. A., McCarthy, A. J., Birchenough, G. M. H., Taylor, P. W. Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat. J. Vis. Exp. (92), e52018, doi:10.3791/52018 (2014).
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