This method creates a tangible, familiar environment for the mouse to navigate and explore during microscopic imaging or single-cell electrophysiological recordings, which require firm fixation of the animal’s head.
Kislin, M., Mugantseva, E., Molotkov, D., Kulesskaya, N., Khirug, S., Kirilkin, I., Pryazhnikov, E., Kolikova, J., Toptunov, D., Yuryev, M., Giniatullin, R., Voikar, V., Rivera, C., Rauvala, H., Khiroug, L. Flat-floored Air-lifted Platform: A New Method for Combining Behavior with Microscopy or Electrophysiology on Awake Freely Moving Rodents. J. Vis. Exp. (88), e51869, doi:10.3791/51869 (2014).