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Coherent anti-Stokes Raman Scattering (CARS) Microscopía visualiza Tablets Farmacéuticos durante la disolución
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工学
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Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution
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Coherent anti-Stokes Raman Scattering (CARS) Microscopía visualiza Tablets Farmacéuticos durante la disolución

17,751 Views

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09:59 min

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July 04, 2014

DOI:

10.3791/51847-v

DOI:
10.3791/51847-v

•

09:59 min
July 04, 2014

•

3 Views
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1Optical Sciences Group, MESA+ Institute,University of Twente, 2Institute of Pharmaceutics and Biopharmaceutics,Heinrich-Heine University, 3Division of Pharmaceutical Technology, Faculty of Pharmacy,University of Helsinki

概要

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Anti-Stokes dispersión Raman (CARS) microscopía coherente se combina con una configuración de disolución de flujo a través intrínseca para permitir in situ y visualización en tiempo real de la superficie de comprimidos farmacéuticos sometidos a la disolución. Utilizando esta configuración a la medida, es posible correlacionar COCHES vídeos con perfiles de disolución de fármacos grabados mediante espectroscopía de absorción UV inline.

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Cite this Article

Fussell, A. L., Kleinebudde, P., Herek, J., Strachan, C. J., Offerhaus, H. L. Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution. J. Vis. Exp. (89), e51847, doi:10.3791/51847 (2014).

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