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Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution
JoVE Journal
Engenharia
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JoVE Journal Engenharia
Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution

Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution

17,790 Views

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09:59 min

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July 04, 2014

DOI:

10.3791/51847-v

DOI:
10.3791/51847-v

•

09:59 min
July 04, 2014

•

3 Views
, , , ,
1Optical Sciences Group, MESA+ Institute,University of Twente, 2Institute of Pharmaceutics and Biopharmaceutics,Heinrich-Heine University, 3Division of Pharmaceutical Technology, Faculty of Pharmacy,University of Helsinki

Summary

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Coherent anti-Stokes Raman scattering (CARS) microscopy is combined with an intrinsic flow-through dissolution setup to allow in situ and real-time visualization of the surface of pharmaceutical tablets undergoing dissolution. Using this custom-built setup, it is possible to correlate CARS videos with drug dissolution profiles recorded using inline UV absorption spectroscopy.

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Fussell, A. L., Kleinebudde, P., Herek, J., Strachan, C. J., Offerhaus, H. L. Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution. J. Vis. Exp. (89), e51847, doi:10.3791/51847 (2014).

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