The Quellung reaction is the gold standard technique for serotyping Streptococcus pneumoniae. This technique utilizes a microscope and specific pneumococcal antisera and is commonly used in reference and research laboratories worldwide.
Habib, M., Porter, B. D., Satzke, C. Capsular Serotyping of Streptococcus pneumoniae Using the Quellung Reaction. J. Vis. Exp. (84), e51208, doi:10.3791/51208 (2014).