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Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
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JoVE Journal 免疫学と感染
Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

14,873 Views

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11:32 min

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February 23, 2014

DOI:

10.3791/51174-v

DOI:
10.3791/51174-v

•

11:32 min
February 23, 2014

•

3 Views
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1Department Genetics of Microorganisms, Interfaculty Institute for Genetics and Functional Genomics,University of Greifswald

概要

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Streptococcus pneumoniae is the leading pathogen causing severe community-acquired pneumonia and responsible for over 2 million deaths worldwide. The impact of bacterial factors implicated in fitness or virulence can be monitored in real-time in an acute mouse pneumonia or bacteremia model using bioluminescent bacteria.

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Cite this Article

Saleh, M., Abdullah, M. R., Schulz, C., Kohler, T., Pribyl, T., Jensch, I., Hammerschmidt, S. Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria. J. Vis. Exp. (84), e51174, doi:10.3791/51174 (2014).

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