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Multi-target Parallel Processing Approccio per Gene-to-struttura Determinazione della polimerasi Influenza PB2 subunità
JoVE Journal
免疫学と感染
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JoVE Journal 免疫学と感染
Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit
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Multi-target Parallel Processing Approccio per Gene-to-struttura Determinazione della polimerasi Influenza PB2 subunità

12,908 Views

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22:10 min

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June 28, 2013

DOI:

10.3791/4225-v

DOI:
10.3791/4225-v

•

22:10 min
June 28, 2013

•

1 Views
, , , , , , , , , ,
1Protein Crystallization Lab,Emerald Bio, 2Molecular Biology Lab,Emerald Bio, 3Scientific Sales Representative,Emerald Bio, 4Group Leader II,Emerald Bio, 5Group Leader I,Emerald Bio, 6Chair of Advisory Board,Emerald Bio, 7Director of Multi-Target Services,Emerald Bio, 8Senior Project Leader,Emerald Bio, 9Project Leader II & SSGCID Site Manager,Emerald Bio

概要

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Structure-based drug design gioca un ruolo importante nello sviluppo di farmaci. Perseguire obiettivi multipli in parallelo aumenta notevolmente la probabilità di successo per la scoperta di lead. L'articolo che segue mette in evidenza come il Seattle Center Genomica strutturale di Malattie Infettive utilizza un approccio multi-obiettivo per la determinazione del gene-per-struttura della influenza PB2 A subunità.

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Multi-targetParallel ProcessingGene-to-structure DeterminationInfluenza Polymerase PB2 SubunitPandemic OutbreaksInfluenza Virus InfectionPoint MutationsVirulence FactorAntiviral Drug TargetStructural Genomics ProgramNational Institute Of Allergy And Infectious Disease (NIAID)Emerald BioSeattle Structural Genomics Center For Infectious Disease (SSGCID)Three-dimensional Protein StructuresNIAID Category A-C PathogensStructure-based Drug DesignDrug Development

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Armour, B. L., Barnes, S. R., Moen, S. O., Smith, E., Raymond, A. C., Fairman, J. W., Stewart, L. J., Staker, B. L., Begley, D. W., Edwards, T. E., Lorimer, D. D. Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit. J. Vis. Exp. (76), e4225, doi:10.3791/4225 (2013).

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