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寄生在鸡模型诱导自身免疫性基因驱动恰加斯心脏疾病
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July 29, 2012
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接种<em>克氏锥虫</em>在之前孵化的受精卵呈现寄生虫kDNA minicircle胚胎细胞的基因组中的整合。杂交揭示突变的垂直转移到后代。该的kDNA集成到编码在几个染色体区域和鸡只死亡与自身免疫性炎症心脏疾病。
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Parasite-inducedGenetically-drivenAutoimmuneChagas Heart DiseaseChicken ModelTrypanosoma CruziAcute InfectionsChronic InfectionsChagas DiseaseAutoimmunityParasite PersistenceT. Cruzi InoculationAir ChamberFertilized EggsMature Chicken Immune SystemParasite-free At HatchingParasite Mitochondrial Kinetoplast DNA (kDNA) Minicircle IntegrationTargeted Prime TAIL-PCRSouthern HybridizationsCloningSequencingRuptured Open Reading FramesTranscription FactorsImmune System FactorsPhosphatase (GTPase)Adenylate CyclasePhosphorylases (PKCNF-Kappa B ActivatorPI-3K)MyocarditisRejection Of Target Heart FibersCytotoxic Lymphocytes
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Teixeira, A. R. L., Nitz, N., Bernal, F. M., Hecht, M. M. Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model. J. Vis. Exp. (65), e3716, doi:10.3791/3716 (2012).
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