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Prediction of HIV-1 Coreceptor Usage (Tropism) by Sequence Analysis using a Genotypic Approach
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免疫学と感染
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JoVE Journal 免疫学と感染
Prediction of HIV-1 Coreceptor Usage (Tropism) by Sequence Analysis using a Genotypic Approach

Prediction of HIV-1 Coreceptor Usage (Tropism) by Sequence Analysis using a Genotypic Approach

DOI:
10.3791/3264-v

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07:06 min

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December 01, 2011

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, , , , , , , , , , , ,
1Institute of Virology,University of Cologne, 2Max Planck Institute for Informatics, 3Institute for Immune genetics, 4Department of Gastroenterology, Hepatology and Infectiology,University of Duesseldorf, 5皮膚学部,University of Essen, 6内科学科,University of Cologne, 7Augustinerinnen Hospital

章

  • 00:05標題
  • 02:02Amplification of the V3 Region
  • 03:25Sequencing of the V3 Amplicon
  • 04:08Sequencing Editing, Data Interpretation, and Trophism Prediction
  • 06:31Conclusion

概要

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自動翻訳

The prediction of the coreceptor usage of HIV-1 is required for the administration of a new class of antiretroviral drugs, i.e. coreceptor antagonists. It can be performed by sequence analysis of the env gene and subsequent interpretation through an internet based interpretation system (geno2pheno[coreceptor]).

タグ

HIV-1Coreceptor UsageTropismSequence AnalysisGenotypic ApproachMaravirocCCR5CXCR4Env ProteinR5 VirusX4 VirusEntry InhibitionTarget CellTrofile AssayMOTIVATE StudyMERIT Study1029 StudyMonogram AssayRecombinant TestsResistance Testing

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