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Associated Chromosome Trap for Identifying Long-range DNA Interactions
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生物学
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JoVE Journal 生物学
Associated Chromosome Trap for Identifying Long-range DNA Interactions

Associated Chromosome Trap for Identifying Long-range DNA Interactions

14,248 Views

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14:49 min

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April 23, 2011

DOI:

10.3791/2621-v

DOI:
10.3791/2621-v

•

14:49 min
April 23, 2011

•

2 Views
,
1Medical Service, VA Palo Alto Health Care System ,Stanford University School of Medicine

概要

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The associated chromosome trap (ACT) assay is a novel unbiased method for identifying long-range DNA interactions. The characterization of long range DNA interactions will allow us to determine the relationship of nuclear architecture to gene expression in both normal physiology and in diseased states.

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Associated Chromosome TrapLong-range DNA InteractionsChromatin StructureChromosome TerritoriesGene ExpressionTranscriptional FactoriesCo-localizationACT AssayChromosome Conformation Capture TechniqueTranscriptional RegulationNuclear ArchitectureGene Expression In Disease States

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Cite this Article

Ling, J., Hoffman, A. R. Associated Chromosome Trap for Identifying Long-range DNA Interactions. J. Vis. Exp. (50), e2621, doi:10.3791/2621 (2011).

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