We have developed a computer program to analyze neuronal morphology. In combination with two existing open source analysis tools, our program performs Sholl analysis and determines the number of neurites, branch points, and neurite tips. The analyses are performed so that local changes in neurite morphology can be observed.
Kutzing, M. K., Langhammer, C. G., Luo, V., Lakdawala, H., Firestein, B. L. Automated Sholl Analysis of Digitized Neuronal Morphology at Multiple Scales. J. Vis. Exp. (45), e2354, doi:10.3791/2354 (2010).