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Targeting of Deep Brain Structures with Microinjections for Delivery of Drugs, Viral Vectors, or Cell Transplants
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JoVE Journal 神経科学
Targeting of Deep Brain Structures with Microinjections for Delivery of Drugs, Viral Vectors, or Cell Transplants

Targeting of Deep Brain Structures with Microinjections for Delivery of Drugs, Viral Vectors, or Cell Transplants

12,335 Views

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07:00 min

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December 01, 2010

DOI:

10.3791/2082-v

DOI:
10.3791/2082-v

•

07:00 min
December 01, 2010

•

5 Views
, ,
1 Neuroscience Lab/ Fac. Psicologia,University of Colima, 2Department of Neurosurgery,Johns Hopkins University

概要

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In this article, we show a method to make glass capillary needles with a 50-μm lumen. This technique significantly reduces the brain damage, minimizes passive diffusion of drugs and allows a precise targeting into the rodent brain.

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Deep Brain StructuresMicroinjectionsDrug DeliveryViral VectorsCell TransplantsBrain ParenchymaInjecting NeedleBrain LesionMouse BrainGlass Capillary NeedlesBrain DamagePrecise TargetingRodent BrainSmall VolumesBleeding RisksPassive DiffusionInjection TechniquesCollateral Damage

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Cite this Article

Gonzalez-Perez, O., Guerrero-Cazares, H., Quiñones-Hinojosa, A. Targeting of Deep Brain Structures with Microinjections for Delivery of Drugs, Viral Vectors, or Cell Transplants. J. Vis. Exp. (46), e2082, doi:10.3791/2082 (2010).

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